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Catalog Number:
33036
CAS Number:
123714-50-1
Acetyl-Calpastatin (184-210) (human) trifluoroacetate salt
Purity:
≥ 95% (HPLC)
Synonym(s):
Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2 trifluoroacetate salt, Acetyl-Calpain Inhibitor Fragment (184-210) (human)
Documents
$273.61 /1MG
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Product Information

Acetyl-Calpastatin (184-210) (human) trifluoroacetate salt is a specialized peptide that plays a crucial role in the regulation of calpain activity, a family of calcium-dependent cysteine proteases involved in various cellular processes, including apoptosis and muscle function. This compound is particularly valuable in research settings focused on muscle biology, neurodegenerative diseases, and cellular signaling pathways. Its unique structure allows it to effectively inhibit calpain, making it a potent tool for studying calpain-related mechanisms in both in vitro and in vivo models. Researchers can leverage Acetyl-Calpastatin to explore therapeutic strategies for conditions such as muscular dystrophy and Alzheimer's disease, where calpain dysregulation is implicated.

In addition to its research applications, Acetyl-Calpastatin offers advantages over similar compounds due to its enhanced stability and specificity, which can lead to more reliable experimental outcomes. Its trifluoroacetate salt form improves solubility, facilitating easier handling and incorporation into various experimental protocols. This compound is essential for professionals seeking to deepen their understanding of proteolytic processes and develop targeted interventions in related diseases.

Synonyms
Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2 trifluoroacetate salt, Acetyl-Calpain Inhibitor Fragment (184-210) (human)
CAS Number
123714-50-1
Purity
≥ 95% (HPLC)
Molecular Formula
C142H230N36O44S·C2HF3O2
Molecular Weight
3291.69
MDL Number
MFCD32012115
PubChem ID
134160232
Appearance
White to off-white powder
Conditions
Store at ≤ -10 °C
General Information
Synonyms
Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2 trifluoroacetate salt, Acetyl-Calpain Inhibitor Fragment (184-210) (human)
CAS Number
123714-50-1
Purity
≥ 95% (HPLC)
Molecular Formula
C142H230N36O44S·C2HF3O2
Molecular Weight
3291.69
MDL Number
MFCD32012115
PubChem ID
134160232
Appearance
White to off-white powder
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Acetyl-Calpastatin (184-210) (human) trifluoroacetate salt is widely utilized in research focused on:

  • Cellular Research: This compound is used to study calpain activity, which plays a crucial role in cellular signaling and apoptosis. Researchers can investigate how calpastatin regulates calpain and its implications in diseases.
  • Neuroscience: It aids in understanding neurodegenerative diseases by inhibiting calpain, which is linked to neuronal damage. This application is vital for developing therapeutic strategies for conditions like Alzheimer's and Parkinson's disease.
  • Drug Development: The compound serves as a valuable tool in screening potential calpain inhibitors, which can lead to new drug candidates for various diseases, enhancing the drug discovery process.
  • Muscle Biology: It is used to explore muscle degeneration and regeneration mechanisms, providing insights that can help in developing treatments for muscle-related disorders.
  • Biochemical Assays: Acetyl-Calpastatin is employed in assays to measure calpain activity, offering a reliable method for researchers to quantify and analyze calpain's role in different biological processes.

Citations