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Catalog Number:
32499
CAS Number:
27848-84-6
Nicergoline
Purity:
≥ 98%(HPLC,T)
Synonym(s):
5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methylester, [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl5-bromopyridine-3-carboxylate
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$65.40 /250MG
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Product Information

Nicergoline is a potent nootropic compound recognized for its cognitive-enhancing properties. This indole-quinoline derivative is primarily utilized in the treatment of cognitive disorders, particularly in elderly patients experiencing memory impairment and other age-related cognitive declines. Its mechanism of action involves the modulation of neurotransmitter systems, which can lead to improved cerebral blood flow and enhanced synaptic plasticity. Researchers and healthcare professionals have noted its potential in improving cognitive function, attention, and memory, making it a valuable asset in both clinical and research settings.

In addition to its cognitive benefits, Nicergoline has shown promise in neuroprotective applications, potentially aiding in the management of neurodegenerative diseases. Its unique structure allows for a favorable pharmacokinetic profile, contributing to its efficacy and safety in long-term use. As a result, Nicergoline is increasingly being explored for its applications in various therapeutic areas, including stroke recovery and dementia management, providing a multifaceted approach to enhancing brain health and function.

Synonyms
5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methylester, [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl5-bromopyridine-3-carboxylate
CAS Number
27848-84-6
Purity
≥ 98%(HPLC,T)
Molecular Formula
C24H26BrN3O3
Molecular Weight
484.39
MDL Number
MFCD00869626
PubChem ID
4475
Melting Point
134 - 138 °C
Appearance
White or yellowish powder
Optical Rotation
[a]20/D= +5.2 to +6.2° (C=5 in EtOH(95vol%))
Conditions
Store at 2-8 °C
General Information
Synonyms
5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methylester, [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl5-bromopyridine-3-carboxylate
CAS Number
27848-84-6
Purity
≥ 98%(HPLC,T)
Molecular Formula
C24H26BrN3O3
Molecular Weight
484.39
MDL Number
MFCD00869626
PubChem ID
4475
Melting Point
134 - 138 °C
Appearance
White or yellowish powder
Optical Rotation
[a]20/D= +5.2 to +6.2° (C=5 in EtOH(95vol%))
Conditions
Store at 2-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Nicergoline is widely utilized in research focused on:

  • Cognitive Enhancement: This compound is often studied for its potential to improve cognitive function, particularly in elderly patients suffering from cognitive decline. Researchers explore its effects on memory and attention, making it relevant in geriatric medicine.
  • Vascular Health: Nicergoline is known for its vasodilatory properties, which help improve blood flow. This application is beneficial in treating conditions like peripheral vascular disease, where enhanced circulation can alleviate symptoms.
  • Neuroprotective Effects: Studies indicate that Nicergoline may protect neurons from damage, making it a subject of interest in neurodegenerative disease research, such as Alzheimer's and Parkinson's disease.
  • Ophthalmology: The compound is explored for its potential benefits in treating age-related macular degeneration (AMD) by improving retinal blood flow, which is crucial for maintaining vision in older adults.
  • Pharmaceutical Formulations: Nicergoline is often included in various formulations aimed at enhancing cognitive function and improving quality of life in patients with vascular-related cognitive impairment, showcasing its versatility in the pharmaceutical industry.

Citations