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Catalog Number:
32484
CAS Number:
136572-09-3
Irinotecan hydrochloride trihydrate
Grade:
USP
Purity:
98 - 102% (Assay on anhydrous basis)
Synonym(s):
CPT-11 trihydrate
Documents
$65.00 /250MG
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Product Information

Irinotecan hydrochloride trihydrate is a potent chemotherapeutic agent primarily utilized in the treatment of colorectal cancer. This compound functions as a topoisomerase I inhibitor, disrupting DNA replication and ultimately leading to cancer cell death. Its unique structure allows for effective targeting of tumor cells while minimizing damage to healthy tissues, making it a preferred choice in combination therapies. Researchers and healthcare professionals appreciate its ability to enhance the efficacy of other anticancer drugs, thereby improving patient outcomes.

In clinical settings, Irinotecan hydrochloride trihydrate has demonstrated significant effectiveness in treating metastatic colorectal cancer, particularly in patients who have not responded to other treatments. Its solubility and stability in aqueous solutions facilitate easy administration, while its favorable pharmacokinetic profile supports its use in various therapeutic regimens. This compound's ongoing research and development highlight its potential in expanding treatment options for various malignancies, making it a valuable asset in oncology.

Synonyms
CPT-11 trihydrate
CAS Number
136572-09-3
Purity
98 - 102% (Assay on anhydrous basis)
Grade
USP
Molecular Formula
C33H38N4O6·HCl·3H2O
Molecular Weight
677.19
MDL Number
MFCD01765731
PubChem ID
22727521
Appearance
Yellowish or almost yellow crystalline powder
Boiling Point
257 °C (Lit.)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
CPT-11 trihydrate
CAS Number
136572-09-3
Purity
98 - 102% (Assay on anhydrous basis)
Grade
USP
Molecular Formula
C33H38N4O6·HCl·3H2O
Molecular Weight
677.19
MDL Number
MFCD01765731
PubChem ID
22727521
Appearance
Yellowish or almost yellow crystalline powder
Boiling Point
257 °C (Lit.)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Irinotecan hydrochloride trihydrate is widely utilized in research focused on:

  • Cancer Treatment: This compound is primarily used in chemotherapy for treating colorectal cancer, providing effective tumor reduction and improved patient outcomes.
  • Pharmaceutical Development: Researchers leverage its properties to develop new formulations and delivery methods, enhancing the efficacy and reducing side effects of cancer therapies.
  • Clinical Trials: It plays a crucial role in clinical studies aimed at evaluating new cancer treatment regimens, helping to establish safety and effectiveness in diverse patient populations.
  • Combination Therapies: Irinotecan is often studied in combination with other anticancer agents, allowing for synergistic effects that can lead to better treatment responses.
  • Biomarker Research: Its use in research helps identify biomarkers for patient stratification, enabling personalized medicine approaches that tailor treatments to individual patient profiles.

Citations