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Catalog Number:
32471
CAS Number:
86639-52-3
7-Ethyl-10-hydroxycamptothecin
Purity:
≥ 99% (HPLC)
Hazmat
Documents
$48.67 /250MG
Pack Size Availability Price
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Product Information

7-Ethyl-10-hydroxycamptothecin is a potent derivative of camptothecin, renowned for its significant anticancer properties. This compound exhibits a unique mechanism of action by inhibiting the enzyme topoisomerase I, which is crucial for DNA replication and transcription. As a result, it has garnered attention in the pharmaceutical industry for its potential use in cancer therapies, particularly in treating various solid tumors and hematological malignancies. Researchers are exploring its efficacy in combination therapies, enhancing the overall therapeutic outcomes while minimizing side effects compared to traditional chemotherapeutics.

In addition to its applications in oncology, 7-Ethyl-10-hydroxycamptothecin is being investigated for its potential in drug delivery systems due to its favorable solubility and stability profiles. This compound's unique structural features allow for modifications that can improve its bioavailability and targeting capabilities, making it a valuable candidate for further development in personalized medicine. Its promising applications in both research and clinical settings highlight its relevance and potential impact in advancing cancer treatment strategies.

CAS Number
86639-52-3
Purity
≥ 99% (HPLC)
Molecular Formula
C22H20N2O5
Molecular Weight
392.4
MDL Number
MFCD00871873
PubChem ID
4014291
Melting Point
217 ?C
Appearance
Pale yellow crystalline powder
Optical Rotation
[a]20D = 21.5 ± 2 º (C=0.5 in DMSO)
Conditions
Store at ≤ -10 °C
General Information
CAS Number
86639-52-3
Purity
≥ 99% (HPLC)
Molecular Formula
C22H20N2O5
Molecular Weight
392.4
MDL Number
MFCD00871873
PubChem ID
4014291
Melting Point
217 ?C
Appearance
Pale yellow crystalline powder
Optical Rotation
[a]20D = 21.5 ± 2 º (C=0.5 in DMSO)
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

7-Ethyl-10-hydroxycamptothecin is widely utilized in research focused on:

  • Cancer Treatment: This compound is being investigated for its potential as an anti-cancer agent, particularly in treating various types of tumors. Its ability to inhibit DNA topoisomerase I makes it a promising candidate in oncology.
  • Pharmaceutical Development: Researchers are exploring its formulation in drug delivery systems, enhancing the bioavailability of cancer therapies. This could lead to more effective treatments with fewer side effects.
  • Combination Therapies: It is being studied in combination with other chemotherapeutic agents to improve treatment efficacy and reduce drug resistance in cancer cells.
  • Biological Research: The compound serves as a valuable tool in cellular and molecular biology studies, helping scientists understand the mechanisms of cancer cell proliferation and apoptosis.
  • Natural Product Synthesis: Its structure inspires synthetic chemists to develop new analogs with improved therapeutic profiles, potentially leading to novel cancer treatments.

Citations