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Catalog Number:
32444
CAS Number:
91421-43-1
9-Aminocamptothecin
Purity:
≥ 96% (HPLC)
Synonym(s):
9-Amino-20-(S)-camptothecin
Documents
$72.31 /5MG
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Product Information

9-Aminocamptothecin is a potent antitumor agent derived from the natural compound camptothecin, known for its ability to inhibit DNA topoisomerase I, an essential enzyme involved in DNA replication and repair. This compound has garnered significant attention in cancer research and therapy due to its effectiveness against various types of tumors, including colorectal and ovarian cancers. Its unique mechanism of action allows for selective targeting of cancer cells, minimizing damage to normal cells, which is a notable advantage over traditional chemotherapeutics.

Researchers and pharmaceutical developers are increasingly exploring 9-Aminocamptothecin for its potential in combination therapies, enhancing the efficacy of existing treatments while reducing side effects. Its solubility and stability make it suitable for formulation into various delivery systems, including liposomes and nanoparticles, further improving its bioavailability and therapeutic index. As the demand for innovative cancer treatments continues to rise, 9-Aminocamptothecin stands out as a promising candidate for advancing cancer therapy and improving patient outcomes.

Synonyms
9-Amino-20-(S)-camptothecin
CAS Number
91421-43-1
Purity
≥ 96% (HPLC)
Molecular Formula
C20H17N3O4
Molecular Weight
363.37
MDL Number
MFCD00909855
PubChem ID
131182
Appearance
Off-white to yellow powder
Conditions
Store at RT
General Information
Synonyms
9-Amino-20-(S)-camptothecin
CAS Number
91421-43-1
Purity
≥ 96% (HPLC)
Molecular Formula
C20H17N3O4
Molecular Weight
363.37
MDL Number
MFCD00909855
PubChem ID
131182
Appearance
Off-white to yellow powder
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

9-Aminocamptothecin is widely utilized in research focused on:

  • Cancer Treatment: This compound is a potent topoisomerase I inhibitor, making it a valuable candidate in developing therapies for various cancers, particularly colorectal and ovarian cancers.
  • Pharmaceutical Development: It serves as a lead compound in the synthesis of new anticancer agents, allowing researchers to modify its structure to enhance efficacy and reduce side effects.
  • Drug Combination Studies: Researchers often explore its effectiveness in combination with other chemotherapeutic agents, aiming to improve treatment outcomes and overcome drug resistance in cancer cells.
  • Biological Research: The compound is used in studies to understand the mechanisms of DNA damage and repair, providing insights into cancer biology and potential therapeutic targets.
  • Formulation Science: Its properties are investigated for developing novel drug delivery systems, enhancing the solubility and bioavailability of anticancer drugs.

Citations