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Catalog Number:
30810
CAS Number:
50-02-2
Dexamethasone
Grade:
meets USP specifications
Purity:
≥ 99% (HPLC)
Synonym(s):
9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F
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Product Information

Dexamethasone is a potent synthetic glucocorticoid with a wide range of applications in both clinical and research settings. Known for its anti-inflammatory and immunosuppressive properties, it is commonly used in the treatment of various conditions such as allergies, autoimmune diseases, and certain types of cancer. Dexamethasone is also employed in managing severe inflammatory responses, such as those seen in COVID-19 patients, where it has been shown to improve survival rates. Its ability to modulate the immune response makes it invaluable in transplant medicine and in the treatment of chronic inflammatory conditions.

In addition to its therapeutic uses, Dexamethasone serves as a critical tool in laboratory research, particularly in studies involving cell signaling and gene expression. Researchers utilize it to induce specific biological responses in cell cultures, allowing for the exploration of various physiological processes. The compound's unique properties, including its high potency and long half-life, provide significant advantages over other corticosteroids, making it a preferred choice for both medical professionals and researchers alike.

Synonyms
9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F
CAS Number
50-02-2
Purity
≥ 99% (HPLC)
Grade
meets USP specifications
Molecular Formula
C22H29FO5
Molecular Weight
392.46
MDL Number
MFCD00064136
PubChem ID
3003
Appearance
A white or almost white crystalline powder
Optical Rotation
=+72 to +80°
Conditions
Store at 0-8 °C
General Information
Synonyms
9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F
CAS Number
50-02-2
Purity
≥ 99% (HPLC)
Grade
meets USP specifications
Molecular Formula
C22H29FO5
Molecular Weight
392.46
MDL Number
MFCD00064136
PubChem ID
3003
Appearance
A white or almost white crystalline powder
Optical Rotation
=+72 to +80°
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Dexamethasone is widely utilized in research focused on:

  • Anti-inflammatory Treatments: It is commonly used in the treatment of various inflammatory conditions, such as arthritis and asthma, providing rapid relief and reducing swelling.
  • Autoimmune Disorders: This compound plays a crucial role in managing autoimmune diseases like lupus and multiple sclerosis, helping to suppress the immune response effectively.
  • Oncology: In cancer therapy, dexamethasone is used to alleviate symptoms related to tumors and to enhance the efficacy of certain chemotherapy regimens.
  • Allergy Management: It is effective in treating severe allergic reactions and conditions such as hay fever, providing quick symptom relief.
  • COVID-19 Treatment: Dexamethasone has been recognized for its role in reducing mortality in severe COVID-19 cases by mitigating the body's inflammatory response to the virus.

Citations