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Catalog Number:
30501
CAS Number:
373614-12-1
Bis-N-succinimidyl diglycolic acid
Purity:
≥ 98% (Assay by titration)
Synonym(s):
2,2'-Oxydiacetic acid bis-N-succinimidyl ester, DIG (NHS)2
Documents
$50.30 /100MG
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Product Information

Bis-N-succinimidyl diglycolic acid is a versatile crosslinking agent widely utilized in bioconjugation and protein labeling applications. This compound features two succinimidyl groups that enhance its reactivity, making it an excellent choice for creating stable linkages between biomolecules, such as proteins, peptides, and nucleic acids. Its unique structure allows for selective modification of amine-containing compounds, facilitating the development of targeted drug delivery systems and diagnostic tools. Researchers appreciate its ability to improve the stability and efficacy of therapeutic agents, particularly in the fields of immunology and molecular biology.

In addition to its applications in bioconjugation, Bis-N-succinimidyl diglycolic acid is also employed in the synthesis of antibody-drug conjugates (ADCs), which are pivotal in cancer therapy. The compound's favorable solubility and reactivity profile make it a preferred choice for professionals seeking reliable and efficient methods for biomolecule modification. With its proven track record in enhancing the performance of therapeutic agents, this compound stands out as a valuable tool for researchers and industry professionals alike.

Synonyms
2,2'-Oxydiacetic acid bis-N-succinimidyl ester, DIG (NHS)2
CAS Number
373614-12-1
Purity
≥ 98% (Assay by titration)
Molecular Formula
C12H12N2O9
Molecular Weight
328.2
MDL Number
MFCD13184975
PubChem ID
51340992
Melting Point
145 - 156 °C
Appearance
White crystalline powder
Conditions
Store at ≤ -4 °C
General Information
Synonyms
2,2'-Oxydiacetic acid bis-N-succinimidyl ester, DIG (NHS)2
CAS Number
373614-12-1
Purity
≥ 98% (Assay by titration)
Molecular Formula
C12H12N2O9
Molecular Weight
328.2
MDL Number
MFCD13184975
PubChem ID
51340992
Melting Point
145 - 156 °C
Appearance
White crystalline powder
Conditions
Store at ≤ -4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Bis-N-succinimidyl diglycolic acid is widely utilized in research focused on:

  • Bioconjugation: This chemical is commonly used to link biomolecules, such as proteins and antibodies, enhancing their functionality for targeted drug delivery systems in pharmaceuticals.
  • Diagnostics: It plays a crucial role in the development of diagnostic assays, where it helps in the immobilization of antigens or antibodies on surfaces, improving the sensitivity and specificity of tests.
  • Vaccine Development: The compound is utilized in formulating vaccines by facilitating the conjugation of antigens to carrier proteins, which can enhance immune responses.
  • Polymer Chemistry: In the field of materials science, it aids in creating cross-linked polymer networks, resulting in materials with desirable mechanical properties for various applications.
  • Research Tools: It serves as a valuable tool in molecular biology for labeling and tracking biomolecules, allowing researchers to study cellular processes with greater precision.

Citations