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Catalog Number:
30326
CAS Number:
1572725-72-4
Fmoc-Gln(Trt)-Thr[Psi(Me,Me)Pro]-OH
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-Gln(Trt)-Thr[Ψ(Me,Me)Pro]-OH, (4S,5R)-3-[Na-(9-Fluorenylmethyloxycarbonyl)-Ng-trityl-L-glutaminyl]-2,2,5-trimethyloxazolidine-4-carboxylicacid
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Product Information

Fmoc-Gln(Trt)-Thr[Psi(Me,Me)Pro]-OH is a sophisticated amino acid derivative that plays a pivotal role in peptide synthesis and drug development. This compound features a unique combination of protective groups, including the Fmoc (fluorenylmethyloxycarbonyl) and Trt (trityl) groups, which facilitate selective reactions and enhance the stability of the peptide during synthesis. Its structural characteristics make it particularly valuable in the production of complex peptides, especially those requiring high purity and specificity. Researchers and industry professionals can leverage this compound in the development of therapeutic peptides, where precision and efficiency are paramount.

The compound's unique oxazolidine structure contributes to its stability and reactivity, making it an excellent choice for applications in medicinal chemistry and biochemistry. Its ability to form stable peptide bonds while maintaining the integrity of sensitive functional groups allows for the synthesis of bioactive peptides with enhanced pharmacological properties. Fmoc-Gln(Trt)-Thr[Psi(Me,Me)Pro]-OH is ideal for use in combinatorial chemistry and high-throughput screening, providing researchers with the tools necessary to explore new therapeutic avenues effectively.

Synonyms
Fmoc-Gln(Trt)-Thr[Ψ(Me,Me)Pro]-OH, (4S,5R)-3-[Na-(9-Fluorenylmethyloxycarbonyl)-Ng-trityl-L-glutaminyl]-2,2,5-trimethyloxazolidine-4-carboxylicacid
CAS Number
1572725-72-4
Purity
≥ 99% (HPLC)
Molecular Formula
C46H45N3O7
Molecular Weight
751.88
MDL Number
MFCD10001377
PubChem ID
129011246
Appearance
White to off-white powder
Optical Rotation
[a]D25 = -21.0 ± 2.5 º (C=1 in MeOH)
Conditions
Store at ≤ -4 °C
General Information
Synonyms
Fmoc-Gln(Trt)-Thr[Ψ(Me,Me)Pro]-OH, (4S,5R)-3-[Na-(9-Fluorenylmethyloxycarbonyl)-Ng-trityl-L-glutaminyl]-2,2,5-trimethyloxazolidine-4-carboxylicacid
CAS Number
1572725-72-4
Purity
≥ 99% (HPLC)
Molecular Formula
C46H45N3O7
Molecular Weight
751.88
MDL Number
MFCD10001377
PubChem ID
129011246
Appearance
White to off-white powder
Optical Rotation
[a]D25 = -21.0 ± 2.5 º (C=1 in MeOH)
Conditions
Store at ≤ -4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-Gln(Trt)-Thr[Psi(Me,Me)Pro]-OH is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing researchers to create complex structures efficiently. Its protective groups facilitate the selective addition of amino acids in a controlled manner.
  • Drug Development: In pharmaceutical research, it is used to develop novel therapeutic peptides. The unique structure enhances stability and bioavailability, making it a valuable candidate for drug formulation.
  • Bioconjugation: The compound is employed in bioconjugation techniques, where it helps attach peptides to other molecules, such as antibodies or drugs, enhancing their targeting capabilities in treatments.
  • Protein Engineering: Researchers utilize this chemical in the modification of proteins, allowing for the introduction of specific functionalities that can improve protein performance in various applications, including diagnostics and therapeutics.
  • Research in Neuroscience: It is also applied in studies related to neuropeptides, aiding in the understanding of neurotransmitter functions and their implications in neurological disorders.

Citations