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Catalog Number:
30305
CAS Number:
920519-32-0
Fmoc-Asp(OtBu)-Thr[Psi(Me,Me)Pro]-OH
Purity:
98 - 101% (Assay by titration)
Synonym(s):
Fmoc-Asp(OtBu)-Thr[Ψ(Me,Me)Pro]-OH, (4S,5R)-3-[Na-(9-Fluorenylmethyloxycarbonyl)-L-aspartyl-tert-butylester]-2,2,5-trimethyloxazolidine-4-carboxylic acid
Antibiotic
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$77.82 /1G
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Product Information

Fmoc-Asp(OtBu)-Thr[Psi(Me,Me)Pro]-OH is a specialized amino acid derivative that plays a crucial role in peptide synthesis and drug development. This compound is particularly valued for its ability to enhance the stability and bioavailability of peptides, making it an essential tool for researchers in the fields of medicinal chemistry and biochemistry. Its unique structure, featuring the Fmoc protecting group and the OtBu side chain, allows for selective reactions and modifications, facilitating the synthesis of complex peptide sequences.

This compound is widely used in the development of peptide-based therapeutics, where precise control over amino acid sequences is critical. Its application extends to the creation of cyclic peptides and peptidomimetics, which are important in designing novel drugs with improved efficacy and reduced side effects. Researchers appreciate its compatibility with various coupling reagents and its ability to withstand harsh reaction conditions, making it a reliable choice for high-throughput peptide synthesis. With its unique properties and versatile applications, Fmoc-Asp(OtBu)-Thr[Psi(Me,Me)Pro]-OH stands out as a valuable asset for professionals in pharmaceutical and academic research settings.

Synonyms
Fmoc-Asp(OtBu)-Thr[Ψ(Me,Me)Pro]-OH, (4S,5R)-3-[Na-(9-Fluorenylmethyloxycarbonyl)-L-aspartyl-tert-butylester]-2,2,5-trimethyloxazolidine-4-carboxylic acid
CAS Number
920519-32-0
Purity
98 - 101% (Assay by titration)
Molecular Formula
C30H36N2O8
Molecular Weight
552.62
MDL Number
MFCD18427721
PubChem ID
129011244
Appearance
White to off-white powder
Optical Rotation
[a]D25 = -21.0 ± 3 ° (C=1 in MeOH)
Conditions
Store at ≤ -4 °C
General Information
Synonyms
Fmoc-Asp(OtBu)-Thr[Ψ(Me,Me)Pro]-OH, (4S,5R)-3-[Na-(9-Fluorenylmethyloxycarbonyl)-L-aspartyl-tert-butylester]-2,2,5-trimethyloxazolidine-4-carboxylic acid
CAS Number
920519-32-0
Purity
98 - 101% (Assay by titration)
Molecular Formula
C30H36N2O8
Molecular Weight
552.62
MDL Number
MFCD18427721
PubChem ID
129011244
Appearance
White to off-white powder
Optical Rotation
[a]D25 = -21.0 ± 3 ° (C=1 in MeOH)
Conditions
Store at ≤ -4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
Yes
DEA-regulated
No
Warnings
-
Applications

Fmoc-Asp(OtBu)-Thr[Psi(Me,Me)Pro]-OH is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex peptide sequences with high purity.
  • Drug Development: It is employed in the development of peptide-based pharmaceuticals, offering potential therapeutic benefits in treating various diseases, including cancer and metabolic disorders.
  • Bioconjugation: The chemical is used in bioconjugation processes, where it aids in attaching peptides to other biomolecules, enhancing the specificity and efficacy of drug delivery systems.
  • Research in Protein Engineering: Researchers utilize this compound to modify proteins, enabling the study of protein interactions and functions, which is crucial for understanding biological processes.
  • Development of Diagnostic Tools: It plays a role in creating diagnostic assays, particularly in immunoassays, where peptides are used as antigens or antibodies, improving the accuracy of disease detection.

Citations