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Catalog Number:
26458
CAS Number:
220932-33-2
Nα-Fmoc-L-histidine allyl ester
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-His-OAll
Documents
$72.31 /250MG
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Product Information

Na-Fmoc-L-histidine allyl ester is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of the amino group during the synthesis of complex peptides. Its allyl ester functionality enhances the reactivity of the carboxylic acid, making it an ideal candidate for coupling reactions in solid-phase peptide synthesis. Researchers appreciate its stability and ease of handling, which facilitate the production of high-purity peptides for various applications, including pharmaceuticals and bioconjugates.

In addition to its role in peptide synthesis, Na-Fmoc-L-histidine allyl ester is also valuable in the development of histidine-containing compounds, which are critical in enzyme catalysis and metal ion coordination. Its unique structure allows for the incorporation of histidine into peptides with enhanced biological activity and specificity. This compound is particularly beneficial for researchers focusing on drug design and development, as it provides a reliable method for creating histidine-rich peptides that can interact effectively with biological targets.

Synonyms
Fmoc-L-His-OAll
CAS Number
220932-33-2
Purity
≥ 99% (HPLC)
Molecular Formula
C24H23N3O4
Molecular Weight
417.46
MDL Number
MFCD04973178
PubChem ID
73194116
Melting Point
102-107 °C
Appearance
White crystalline powder
Optical Rotation
[α]D = -20 ± 2º (C=1 in MeOH)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-His-OAll
CAS Number
220932-33-2
Purity
≥ 99% (HPLC)
Molecular Formula
C24H23N3O4
Molecular Weight
417.46
MDL Number
MFCD04973178
PubChem ID
73194116
Melting Point
102-107 °C
Appearance
White crystalline powder
Optical Rotation
[α]D = -20 ± 2º (C=1 in MeOH)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-L-histidine allyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex and biologically active molecules.
  • Drug Development: It is used in the development of pharmaceuticals, especially in designing histidine-containing compounds that can enhance drug efficacy and stability.
  • Bioconjugation: The allyl ester group allows for selective reactions in bioconjugation processes, facilitating the attachment of biomolecules to surfaces or other compounds, which is crucial in creating targeted therapies.
  • Research in Protein Engineering: This chemical aids researchers in modifying proteins to study their functions and interactions, providing insights into enzyme activity and protein structure.
  • Diagnostic Applications: Its derivatives can be employed in diagnostic assays, particularly in detecting specific biomarkers related to diseases, enhancing the sensitivity and specificity of tests.

Citations