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Catalog Number:
23030
CAS Number:
80307-12-6
4-Maleimidobutyric acid -NHS ester
Purity:
≥ 97% (HPLC)
Synonym(s):
GMBS, 4-Maleimidobutyric acid N-hydroxysuccinimide ester
Documents
$20.00 /250MG
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Product Information

4-Maleimidobutyric acid NHS is a versatile compound widely utilized in bioconjugation and protein labeling applications. This compound features a maleimide group that allows for selective conjugation with thiol-containing molecules, making it an essential tool in the fields of biochemistry and molecular biology. Its unique structure enhances stability and reactivity, enabling researchers to create stable linkages between proteins, peptides, and other biomolecules. This capability is particularly valuable in the development of targeted drug delivery systems and diagnostic assays, where precise molecular interactions are crucial.

In addition to its use in bioconjugation, 4-Maleimidobutyric acid NHS is also employed in the synthesis of antibody-drug conjugates (ADCs), which are pivotal in cancer therapy. By facilitating the attachment of cytotoxic agents to antibodies, this compound plays a significant role in enhancing the efficacy of therapeutic treatments while minimizing side effects. Its ability to form stable conjugates under physiological conditions further underscores its importance in research and clinical applications, making it a preferred choice for professionals seeking reliable and effective solutions in their work.

Synonyms
GMBS, 4-Maleimidobutyric acid N-hydroxysuccinimide ester
CAS Number
80307-12-6
Purity
≥ 97% (HPLC)
Molecular Formula
C12H12N2O6
Molecular Weight
280.24
MDL Number
MFCD00036817
PubChem ID
133440
Melting Point
124-125 °C
Appearance
White to off-white powder
Conditions
Store at 0-8 °C
General Information
Synonyms
GMBS, 4-Maleimidobutyric acid N-hydroxysuccinimide ester
CAS Number
80307-12-6
Purity
≥ 97% (HPLC)
Molecular Formula
C12H12N2O6
Molecular Weight
280.24
MDL Number
MFCD00036817
PubChem ID
133440
Melting Point
124-125 °C
Appearance
White to off-white powder
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

4-Maleimidobutyric acid NHS is widely utilized in research focused on:

  • Bioconjugation: This compound is commonly used to link biomolecules, such as proteins and peptides, enhancing their stability and functionality for therapeutic applications.
  • Drug Development: In the pharmaceutical industry, it plays a crucial role in creating targeted drug delivery systems, allowing for more effective treatments with reduced side effects.
  • Diagnostics: It is employed in the development of diagnostic assays, facilitating the detection of specific biomolecules in various medical tests.
  • Protein Labeling: Researchers use it for labeling proteins with fluorescent tags, which aids in studying protein interactions and cellular processes.
  • Vaccine Development: The compound is also significant in the formulation of vaccines, helping to improve the immune response by effectively linking antigens to carriers.

Citations