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Catalog Number:
23013
CAS Number:
57757-57-0
Dithio-bis-succinimidyl propionate (Lomant's Reagent)
Purity:
≥ 98% (Assay)
Synonym(s):
3,3'-Dithiobis(succinimidyl propionate)
Documents
$75.00 /100MG
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Product Information

Dithio-bis-succinimidyl propionate, commonly known as Lomant's Reagent, is a versatile crosslinking agent widely utilized in biochemical research and bioconjugation applications. This compound is particularly valued for its ability to form stable thioether linkages between proteins, peptides, and other biomolecules, making it an essential tool in the development of targeted drug delivery systems and protein engineering. Researchers appreciate its efficiency in facilitating the conjugation of various functional groups, which enhances the stability and efficacy of therapeutic agents.

Lomant's Reagent is especially beneficial in applications such as the preparation of antibody-drug conjugates, where precise control over the linkage between the antibody and the drug is crucial for therapeutic effectiveness. Its unique properties allow for selective modification of biomolecules, enabling the creation of complex molecular architectures that can improve the pharmacokinetics and biodistribution of drugs. With its proven track record in enhancing the performance of biopharmaceuticals, Lomant's Reagent stands out as a reliable choice for researchers aiming to innovate in the fields of drug development and molecular biology.

Synonyms
3,3'-Dithiobis(succinimidyl propionate)
CAS Number
57757-57-0
Purity
≥ 98% (Assay)
Molecular Formula
C14H16N2S2O8
Molecular Weight
404.42
MDL Number
MFCD00042045
PubChem ID
93313
Melting Point
128 - 132 °C (Lit.)
Appearance
White to off-white solid/Powder
Conditions
Store at 0 - 8 °C
General Information
Synonyms
3,3'-Dithiobis(succinimidyl propionate)
CAS Number
57757-57-0
Purity
≥ 98% (Assay)
Molecular Formula
C14H16N2S2O8
Molecular Weight
404.42
MDL Number
MFCD00042045
PubChem ID
93313
Melting Point
128 - 132 °C (Lit.)
Appearance
White to off-white solid/Powder
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Dithio-bis-succinimidyl propionate (Lomant's Reagent) is widely utilized in research focused on

  • Protein Cross-Linking: This compound is commonly used to create stable cross-links between proteins, which is essential in studying protein interactions and structures in biochemistry.
  • Bioconjugation: It serves as an effective tool for attaching biomolecules, such as antibodies or enzymes, to surfaces or other molecules, enhancing the functionality of diagnostic and therapeutic agents.
  • Drug Delivery Systems: Researchers leverage its properties to develop advanced drug delivery systems, allowing for targeted release of therapeutics, improving efficacy while minimizing side effects.
  • Vaccine Development: The reagent is instrumental in the formulation of vaccines by aiding in the conjugation of antigens to carriers, which can enhance immune responses.
  • Material Science: In materials research, it is used for modifying surfaces to improve adhesion and compatibility of various materials, which is crucial for developing new composite materials.

Citations