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Catalog Number:
22658
CAS Number:
959576-18-2
(2S,4R)-Fmoc-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid
Purity:
≥ 97% (HPLC)
Synonym(s):
(2S,4R)-Fmoc-4-(4-fluorobenzyl)-Pro-OH
Documents
$248.37 /100MG
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Product Information

The compound (2S,4R)-Fmoc-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid is a valuable building block in peptide synthesis and drug development. Its unique structure, featuring a fluorobenzyl group, enhances its utility in medicinal chemistry, particularly in the design of bioactive compounds. This compound is widely recognized for its role in the synthesis of peptide-based therapeutics, where the Fmoc (9-fluorenylmethyloxycarbonyl) protecting group allows for selective deprotection during the synthesis process. Researchers appreciate its stability and compatibility with various coupling reagents, making it an ideal choice for complex peptide sequences.

In addition to its applications in peptide synthesis, this compound's fluorinated moiety can improve the pharmacokinetic properties of the resulting peptides, potentially leading to enhanced bioavailability and therapeutic efficacy. Its relevance extends to the fields of drug discovery and development, where it can be utilized to create targeted therapies for various diseases. The compound's unique features, such as its ability to facilitate the synthesis of challenging peptide sequences, position it as a preferred choice for researchers and industry professionals seeking innovative solutions in pharmaceutical development.

Synonyms
(2S,4R)-Fmoc-4-(4-fluorobenzyl)-Pro-OH
CAS Number
959576-18-2
Purity
≥ 97% (HPLC)
Molecular Formula
C27H24NO4F
Molecular Weight
445.49
MDL Number
MFCD06656470
PubChem ID
4712590
Appearance
White powder
Optical Rotation
[a]D25 = -22.4 ± 2 ° (C=1 in CHCl3)
Conditions
Store at 0-8 °C
General Information
Synonyms
(2S,4R)-Fmoc-4-(4-fluorobenzyl)-Pro-OH
CAS Number
959576-18-2
Purity
≥ 97% (HPLC)
Molecular Formula
C27H24NO4F
Molecular Weight
445.49
MDL Number
MFCD06656470
PubChem ID
4712590
Appearance
White powder
Optical Rotation
[a]D25 = -22.4 ± 2 ° (C=1 in CHCl3)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

(2S,4R)-Fmoc-4-(4-fluorobenzyl)pyrrolidine-2-carboxylic acid is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, where its Fmoc protecting group allows for selective deprotection during the synthesis process.
  • Drug Development: Its unique structure makes it valuable in the pharmaceutical industry for developing new drugs, especially those targeting specific receptors or enzymes due to its ability to modify biological activity.
  • Bioconjugation: The compound can be used in bioconjugation techniques, linking biomolecules to create targeted therapies or diagnostic agents, enhancing the effectiveness of treatments.
  • Research in Neuroscience: It is utilized in studies related to neurotransmitter systems, helping researchers understand the role of specific receptors in neurological processes.
  • Fluorinated Compound Applications: The presence of fluorine in its structure provides unique properties, making it useful in developing compounds with enhanced metabolic stability and bioavailability compared to non-fluorinated analogs.

Citations