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Catalog Number:
22235
CAS Number:
599-79-1
Sulfasalazine
Purity:
≥ 95% (T)(HPLC)
Synonym(s):
5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, 2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoicacid
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Product Information

Sulfasalazine is a well-established anti-inflammatory compound primarily used in the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. This sulfonamide derivative is recognized for its ability to inhibit the production of pro-inflammatory cytokines, making it a valuable therapeutic agent in managing chronic inflammatory conditions. Its unique structure allows for targeted delivery to the colon, enhancing its efficacy while minimizing systemic side effects.

In addition to its primary use in gastroenterology, sulfasalazine has also shown promise in treating rheumatoid arthritis and other autoimmune disorders. Researchers appreciate its dual action as both an anti-inflammatory and immunomodulatory agent, which can be particularly beneficial in combination therapies. The compound's favorable safety profile and established history of use make it a reliable choice for healthcare professionals seeking effective treatment options for their patients.

Synonyms
5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, 2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoicacid
CAS Number
599-79-1
Purity
≥ 95% (T)(HPLC)
Molecular Formula
C18H14N4O5S
Molecular Weight
398.39
MDL Number
MFCD00057363
PubChem ID
5339
Melting Point
246 °C (dec.)
Appearance
Light yellow to amber to dark green powder to crystal
Conditions
Store at RT
General Information
Synonyms
5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, 2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoicacid
CAS Number
599-79-1
Purity
≥ 95% (T)(HPLC)
Molecular Formula
C18H14N4O5S
Molecular Weight
398.39
MDL Number
MFCD00057363
PubChem ID
5339
Melting Point
246 °C (dec.)
Appearance
Light yellow to amber to dark green powder to crystal
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Sulfasalazine is widely utilized in research focused on:

  • Rheumatology: It is primarily used to treat rheumatoid arthritis and inflammatory bowel diseases, helping to reduce inflammation and alleviate symptoms.
  • Antimicrobial Research: Sulfasalazine has shown potential in studies investigating its effects against certain bacterial infections, providing insights into new therapeutic applications.
  • Drug Development: Researchers explore its chemical structure to design new compounds with improved efficacy and reduced side effects, enhancing treatment options for chronic conditions.
  • Clinical Trials: It is often included in clinical studies to evaluate its effectiveness in combination therapies, particularly in autoimmune diseases, offering patients more comprehensive care.
  • Pharmaceutical Formulations: The compound is used in developing various dosage forms, such as tablets and suspensions, ensuring patient compliance and ease of administration.

Citations