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Catalog Number:
22100
CAS Number:
9041-93-4
Bleomycin sulfate from Streptomyces Verticillus
Grade:
USP
Purity:
Assay : Bleomycin A2 : 55 - 70% Bleomycin B2 : 25 - 32% Bleomycin A2+ B2 : ≥ 90% Bleomycin B4 : ≤ 1%
Synonym(s):
Blenoxane, Bleo, Blexane
Documents
$60.40 /5MG
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Product Information

Bleomycin sulfate from Streptomyces Verticillus is a potent glycopeptide antibiotic renowned for its unique ability to induce DNA strand breaks, making it a valuable agent in cancer chemotherapy. This compound is particularly effective against a variety of tumors, including testicular cancer, Hodgkin's lymphoma, and squamous cell carcinomas. Its mechanism of action involves the formation of free radicals that interact with DNA, leading to cytotoxic effects that inhibit cell proliferation. Researchers and healthcare professionals appreciate Bleomycin sulfate for its relatively low myelosuppressive effects compared to other chemotherapeutic agents, allowing for a more favorable safety profile in patients.

In addition to its therapeutic applications, Bleomycin sulfate is also utilized in research settings, particularly in studies focused on DNA damage and repair mechanisms. Its unique properties make it an essential tool for scientists investigating the effects of oxidative stress on cellular processes. With its proven efficacy and versatility, Bleomycin sulfate remains a critical compound in both clinical and research environments, offering significant benefits in the fight against cancer and advancing our understanding of molecular biology.

Synonyms
Blenoxane, Bleo, Blexane
CAS Number
9041-93-4
Purity
Assay : Bleomycin A2 : 55 - 70% Bleomycin B2 : 25 - 32% Bleomycin A2+ B2 : ≥ 90% Bleomycin B4 : ≤ 1%
Grade
USP
Molecular Weight
0
MDL Number
MFCD00070310
PubChem ID
21864427
Appearance
White to off-white amorphous powder
Potency
1.5 - 2.0 U/mg (as is basis)
General Information
Synonyms
Blenoxane, Bleo, Blexane
CAS Number
9041-93-4
Purity
Assay : Bleomycin A2 : 55 - 70% Bleomycin B2 : 25 - 32% Bleomycin A2+ B2 : ≥ 90% Bleomycin B4 : ≤ 1%
Grade
USP
Molecular Weight
0
MDL Number
MFCD00070310
PubChem ID
21864427
Appearance
White to off-white amorphous powder
Potency
1.5 - 2.0 U/mg (as is basis)
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Bleomycin sulfate from Streptomyces Verticillus is widely utilized in research focused on:

  • Cancer Treatment: This compound is primarily known for its role as an antitumor agent, particularly in treating testicular cancer and Hodgkin's lymphoma. Its ability to induce DNA damage in cancer cells makes it a valuable tool in oncology.
  • Research in Cell Biology: Researchers use bleomycin to study the mechanisms of DNA repair and apoptosis. By inducing specific types of DNA damage, scientists can explore how cells respond to stress and the pathways involved in cell death.
  • Veterinary Medicine: In veterinary applications, bleomycin is sometimes used to treat certain types of tumors in animals, providing an alternative treatment option for veterinarians dealing with malignancies.
  • Gene Therapy Research: Bleomycin's unique properties make it a candidate for studies in gene therapy, particularly in understanding how to deliver therapeutic genes effectively while minimizing damage to surrounding healthy tissue.
  • Pharmaceutical Development: The compound is also significant in the development of new drugs, as its mechanisms of action can inspire the design of novel anticancer therapies that target similar pathways.

Citations