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Catalog Number:
16961
CAS Number:
920519-31-9
Fmoc-Tyr(tBu)-Thr[Psi(Me,Me)Pro]-OH
Purity:
99.5 - 101.5% (Assay by titration)
Synonym(s):
Fmoc-Tyr(tBu)-Thr(ΨMe,Mepro)-OH, (4S,5R)-3-[Na-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-tyrosinyl]-2,2,5-trimethyloxazolidine-4-carboxylic acid
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Product Information

Fmoc-Tyr(tBu)-Thr[Psi(Me,Me)Pro]-OH is a specialized amino acid derivative that plays a crucial role in peptide synthesis and drug development. This compound is particularly valued in the field of medicinal chemistry and biochemistry due to its ability to enhance the stability and bioavailability of peptides. The Fmoc (fluorenylmethyloxycarbonyl) protecting group allows for selective deprotection during synthesis, making it an essential tool for researchers working on complex peptide sequences. Its unique structure, featuring a tert-butyl (tBu) group and a Psi(Me,Me)Pro configuration, contributes to its effectiveness in stabilizing peptide conformations, which is vital for the development of therapeutics targeting specific biological pathways.

In practical applications, Fmoc-Tyr(tBu)-Thr[Psi(Me,Me)Pro]-OH is utilized in the synthesis of cyclic peptides and peptidomimetics, which have shown promise in various therapeutic areas, including cancer treatment and antimicrobial agents. The compound's ability to improve peptide solubility and reduce susceptibility to enzymatic degradation makes it a preferred choice among researchers. Its unique features not only enhance the efficiency of peptide synthesis but also open avenues for innovative drug design, making it a valuable asset for professionals in pharmaceutical and biotechnology industries.

Synonyms
Fmoc-Tyr(tBu)-Thr(ΨMe,Mepro)-OH, (4S,5R)-3-[Na-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-tyrosinyl]-2,2,5-trimethyloxazolidine-4-carboxylic acid
CAS Number
920519-31-9
Purity
99.5 - 101.5% (Assay by titration)
Molecular Formula
C35H40N2O7
Molecular Weight
600.7
MDL Number
MFCD08064321
PubChem ID
129011258
Appearance
White to off-white powder
Conditions
Store at ≤ -4 °C
General Information
Synonyms
Fmoc-Tyr(tBu)-Thr(ΨMe,Mepro)-OH, (4S,5R)-3-[Na-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-tyrosinyl]-2,2,5-trimethyloxazolidine-4-carboxylic acid
CAS Number
920519-31-9
Purity
99.5 - 101.5% (Assay by titration)
Molecular Formula
C35H40N2O7
Molecular Weight
600.7
MDL Number
MFCD08064321
PubChem ID
129011258
Appearance
White to off-white powder
Conditions
Store at ≤ -4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-Tyr(tBu)-Thr[Psi(Me,Me)Pro]-OH is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing researchers to create complex structures with specific amino acid sequences for drug development and biological studies.
  • Drug Design: Its unique structure enhances the stability and bioavailability of peptide-based drugs, making it valuable in pharmaceutical research aimed at developing new therapeutic agents.
  • Bioconjugation: The compound can be used to modify biomolecules for targeted delivery systems, improving the efficacy of treatments in fields like cancer therapy and immunology.
  • Protein Engineering: Researchers utilize this chemical to introduce specific modifications in proteins, aiding in the study of protein function and interactions, which is crucial for understanding various biological processes.
  • Analytical Chemistry: It is employed in the development of assays and analytical techniques, helping scientists to detect and quantify biomolecules in complex samples, thus supporting various research applications.

Citations