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Catalog Number:
16945
CAS Number:
122350-52-1
Nα-Fmoc-L-glutamic acid α-benzyl ester
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Glu-OBzl
Documents
$65.40 /1G
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Product Information

Na-Fmoc-L-glutamic acid a-benzyl ester is a versatile compound widely utilized in peptide synthesis and pharmaceutical research. This derivative of L-glutamic acid features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino acids during solid-phase peptide synthesis. Its unique structure not only enhances the stability of the amino acid but also facilitates the formation of complex peptides, making it an invaluable tool for researchers in the fields of biochemistry and medicinal chemistry.

The compound's benzyl ester functionality provides additional hydrophobic characteristics, which can improve solubility and enhance the overall yield of peptide synthesis reactions. This makes Na-Fmoc-L-glutamic acid a-benzyl ester particularly advantageous for the development of peptide-based therapeutics and drug candidates. Researchers can leverage its properties to create more effective and targeted treatments, especially in the realm of cancer therapy and other diseases where peptide hormones play a critical role.

Synonyms
Fmoc-L-Glu-OBzl
CAS Number
122350-52-1
Purity
≥ 98% (HPLC)
Molecular Formula
C27H25NO6
Molecular Weight
459.5
MDL Number
MFCD00080272
PubChem ID
75628880
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -17 ± 2º (C=1 in MeOH)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Glu-OBzl
CAS Number
122350-52-1
Purity
≥ 98% (HPLC)
Molecular Formula
C27H25NO6
Molecular Weight
459.5
MDL Number
MFCD00080272
PubChem ID
75628880
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -17 ± 2º (C=1 in MeOH)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-L-glutamic acid a-benzyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex peptide chains with high purity.
  • Drug Development: It plays a significant role in pharmaceutical research, where it can be used to develop new drug candidates that target specific biological pathways, enhancing therapeutic efficacy.
  • Bioconjugation: The chemical is valuable in bioconjugation techniques, facilitating the attachment of biomolecules to drugs or imaging agents, which improves targeting and reduces side effects.
  • Protein Engineering: Researchers utilize it in protein engineering to modify proteins for better stability and activity, which is crucial in developing novel enzymes and therapeutic proteins.
  • Academic Research: It is frequently used in academic laboratories for various studies, including the exploration of amino acid functionalities and their interactions in biological systems.

Citations