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Catalog Number:
16801
CAS Number:
923012-40-2
Fmoc-D-cyclopropylglycine
Purity:
≥ 99% (HPLC, Chiral purity)
Synonym(s):
Fmoc-(R-amino-cyclopropyl-acetic acid, Fmoc-D-Cpg-OH
Documents
$86.23 /100MG
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Product Information

Fmoc-D-cyclopropylglycine is a valuable amino acid derivative widely utilized in peptide synthesis and medicinal chemistry. This compound features a cyclopropyl side chain, which imparts unique steric and electronic properties, making it an attractive building block for the development of bioactive peptides. Its Fmoc (9-fluorenylmethoxycarbonyl) protecting group allows for easy incorporation into peptide chains while providing stability during synthesis. Researchers appreciate its role in enhancing the selectivity and potency of peptide-based therapeutics, particularly in the design of inhibitors and modulators for various biological targets.

In addition to its applications in drug discovery, Fmoc-D-cyclopropylglycine is also employed in the development of novel materials and catalysts due to its distinctive structural features. Its ability to influence molecular interactions makes it a key component in the exploration of new therapeutic avenues. With its unique properties and versatility, Fmoc-D-cyclopropylglycine stands out as a crucial tool for researchers aiming to innovate in the fields of pharmaceuticals and materials science.

Synonyms
Fmoc-(R-amino-cyclopropyl-acetic acid, Fmoc-D-Cpg-OH
CAS Number
923012-40-2
Purity
≥ 99% (HPLC, Chiral purity)
Molecular Formula
C20H19NO4
Molecular Weight
337.37
MDL Number
MFCD06659140
PubChem ID
53395539
Appearance
White powder
Optical Rotation
[a]D20 = -15 ± 2º (C=1 in MeOH)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-(R-amino-cyclopropyl-acetic acid, Fmoc-D-Cpg-OH
CAS Number
923012-40-2
Purity
≥ 99% (HPLC, Chiral purity)
Molecular Formula
C20H19NO4
Molecular Weight
337.37
MDL Number
MFCD06659140
PubChem ID
53395539
Appearance
White powder
Optical Rotation
[a]D20 = -15 ± 2º (C=1 in MeOH)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-D-cyclopropylglycine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a valuable building block in the synthesis of peptides, particularly in the development of novel therapeutics. Its unique structure allows for the introduction of cyclopropyl groups, enhancing the biological activity of the resulting peptides.
  • Drug Development: Researchers leverage its properties to create compounds with improved pharmacological profiles. The cyclopropyl moiety can increase metabolic stability and alter binding affinities, making it a key player in medicinal chemistry.
  • Bioconjugation: Fmoc-D-cyclopropylglycine can be used in bioconjugation strategies, allowing scientists to attach drugs or imaging agents to biomolecules. This application is crucial in targeted therapy and diagnostic imaging.
  • Structure-Activity Relationship (SAR) Studies: It plays a significant role in SAR studies, helping researchers understand how modifications to peptide structures affect their biological activity. This knowledge is essential for optimizing drug candidates.
  • Research in Neuroscience: The compound is explored in neuroscience research for its potential to modulate neurotransmitter systems. Its unique properties may lead to the development of new treatments for neurological disorders.

Citations