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Catalog Number:
15139
CAS Number:
160347-94-4
Nα-Fmoc-Nω-nitro-D-arginine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-Arg(NO2)-OH
Documents
$96.34 /250MG
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Product Information

Na-Fmoc-Nw-nitro-D-arginine is a specialized amino acid derivative that plays a crucial role in peptide synthesis and drug development. This compound is particularly valued in the field of biochemistry and pharmaceutical research due to its unique nitro group, which enhances its reactivity and potential for incorporation into peptides. The Fmoc (9-fluorenylmethoxycarbonyl) protecting group allows for selective deprotection, making it an ideal choice for solid-phase peptide synthesis. Researchers utilize Na-Fmoc-Nw-nitro-D-arginine to create peptides with specific biological activities, which can be pivotal in developing therapeutic agents targeting various diseases, including cancer and cardiovascular disorders. Its ability to introduce modifications at the arginine position opens avenues for creating more potent and selective compounds.

In addition to its applications in peptide synthesis, Na-Fmoc-Nw-nitro-D-arginine can also be utilized in the design of novel biomaterials and drug delivery systems. The compound's unique properties allow for enhanced interaction with biological systems, making it a valuable tool for researchers looking to innovate in drug formulation and delivery. With its versatility and effectiveness, Na-Fmoc-Nw-nitro-D-arginine stands out as a key component in advancing research and development in the life sciences.

Synonyms
Fmoc-D-Arg(NO2)-OH
CAS Number
160347-94-4
Purity
≥ 99% (HPLC)
Molecular Formula
C21H23N5O6
Molecular Weight
441.4
MDL Number
MFCD02682438
PubChem ID
5045949
Melting Point
153-158 ºC
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +8 ± 2º (C=2 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-D-Arg(NO2)-OH
CAS Number
160347-94-4
Purity
≥ 99% (HPLC)
Molecular Formula
C21H23N5O6
Molecular Weight
441.4
MDL Number
MFCD02682438
PubChem ID
5045949
Melting Point
153-158 ºC
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +8 ± 2º (C=2 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nw-nitro-D-arginine is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in the development of novel therapeutic agents. Its protective Fmoc group allows for selective deprotection during the synthesis process.
  • Drug Development: Researchers leverage its unique nitro group to explore potential applications in drug design, particularly for targeting specific biological pathways in diseases such as cancer and cardiovascular disorders.
  • Bioconjugation: The compound is valuable in bioconjugation techniques, where it can be used to attach biomolecules to surfaces or other compounds, enhancing the functionality of drugs and diagnostic agents.
  • Research on Nitric Oxide Donors: Its structure allows for investigations into nitric oxide (NO) release, which is crucial for studies related to vascular biology and inflammation, providing insights into new therapeutic strategies.
  • Analytical Chemistry: Na-Fmoc-Nw-nitro-D-arginine is also employed in analytical methods to study interactions between peptides and proteins, aiding in the understanding of biological processes and interactions.

Citations