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Catalog Number:
15118
CAS Number:
210282-32-9
Fmoc-2-iodo-L-phenylalanine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Phe(2-I)-OH, Fmoc-o-iodo-L-Phe-OH, (S-Fmoc-2-amino-3-(2-iodophenyl)propionic acid
Documents
$260.69 /1G
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Product Information

Fmoc-2-iodo-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during solid-phase peptide synthesis. Its unique structure, characterized by the presence of an iodine atom, enhances its reactivity and allows for the incorporation of iodine into peptides, which can be beneficial for various applications, including radiolabeling in medicinal chemistry and the development of novel therapeutic agents.

Researchers and industry professionals appreciate Fmoc-2-iodo-L-phenylalanine for its ability to facilitate the synthesis of complex peptides with improved stability and bioactivity. Its application extends to the development of peptide-based drugs and the study of protein interactions, making it a valuable tool in both academic and pharmaceutical research settings. With its unique properties and practical applications, this compound stands out as an essential resource for those engaged in peptide chemistry and drug discovery.

Synonyms
Fmoc-L-Phe(2-I)-OH, Fmoc-o-iodo-L-Phe-OH, (S-Fmoc-2-amino-3-(2-iodophenyl)propionic acid
CAS Number
210282-32-9
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20INO4
Molecular Weight
513.4
MDL Number
MFCD01632253
PubChem ID
53427492
Melting Point
125-129 °C
Appearance
Off-white powder
Optical Rotation
[a]D25 = -60 to -65º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Phe(2-I)-OH, Fmoc-o-iodo-L-Phe-OH, (S-Fmoc-2-amino-3-(2-iodophenyl)propionic acid
CAS Number
210282-32-9
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20INO4
Molecular Weight
513.4
MDL Number
MFCD01632253
PubChem ID
53427492
Melting Point
125-129 °C
Appearance
Off-white powder
Optical Rotation
[a]D25 = -60 to -65º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-2-iodo-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the incorporation of iodine into peptide sequences, which can be crucial for labeling and detection.
  • Drug Development: Its unique structure makes it valuable in the development of pharmaceuticals, especially in creating compounds that target specific biological pathways, enhancing drug efficacy and selectivity.
  • Bioconjugation: The iodine atom can be used for bioconjugation processes, facilitating the attachment of biomolecules to drugs or imaging agents, which is essential in targeted therapy and diagnostic applications.
  • Research in Cancer Therapy: The compound is being explored for its potential in cancer research, where iodine-containing peptides may improve the targeting of cancer cells, leading to more effective treatments with fewer side effects.
  • Material Science: Fmoc-2-iodo-L-phenylalanine can also be used in the development of novel materials, such as hydrogels, which have applications in tissue engineering and regenerative medicine due to their biocompatibility.

Citations