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Catalog Number:
14864
CAS Number:
152338-45-9
Nα-Fmoc-Nin-formyl-L-tryptophan
Purity:
≥ 99% (HPLC, TLC)
Synonym(s):
Fmoc-L-Trp(For)-OH
Documents
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Product Information

Na-Fmoc-Nin-formyl-L-tryptophan is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which facilitates the selective modification of amino acids during solid-phase peptide synthesis. Its unique structure, combining the indole moiety of tryptophan with a formyl group, enhances its reactivity and allows for the introduction of various functional groups, making it an essential building block in the design of bioactive peptides and pharmaceuticals. Researchers appreciate its stability under standard synthesis conditions, which contributes to higher yields and purity in peptide production.

In addition to its role in peptide synthesis, Na-Fmoc-Nin-formyl-L-tryptophan has potential applications in the development of targeted therapies and drug delivery systems. Its ability to form stable conjugates with other biomolecules opens avenues for creating innovative therapeutic agents. This compound is particularly valuable in the fields of medicinal chemistry and biochemistry, where the precise control of molecular structure is crucial for the efficacy of therapeutic compounds. With its robust performance and adaptability, Na-Fmoc-Nin-formyl-L-tryptophan stands out as a key ingredient for researchers and industry professionals focused on advancing peptide-based technologies.

Synonyms
Fmoc-L-Trp(For)-OH
CAS Number
152338-45-9
Purity
≥ 99% (HPLC, TLC)
Molecular Formula
C27H22N2O5
Molecular Weight
454.48
MDL Number
MFCD08458583
PubChem ID
76401357
Melting Point
188 - 193 °C
Appearance
White or off-white crystalline powder
Optical Rotation
[a]D20 = -23 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Trp(For)-OH
CAS Number
152338-45-9
Purity
≥ 99% (HPLC, TLC)
Molecular Formula
C27H22N2O5
Molecular Weight
454.48
MDL Number
MFCD08458583
PubChem ID
76401357
Melting Point
188 - 193 °C
Appearance
White or off-white crystalline powder
Optical Rotation
[a]D20 = -23 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nin-formyl-L-tryptophan is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences with high purity.
  • Drug Development: It is used in the design of novel pharmaceuticals, especially those targeting neurological disorders, due to its structural similarity to neurotransmitters, facilitating the development of effective drug candidates.
  • Bioconjugation: The compound is valuable in bioconjugation techniques, enabling researchers to attach biomolecules to surfaces or other molecules, which is essential in creating targeted drug delivery systems.
  • Fluorescent Probes: Its unique structure allows it to be used in the development of fluorescent probes for imaging applications in biological research, enhancing the visualization of cellular processes.
  • Research in Tryptophan Metabolism: This compound aids in studies related to tryptophan metabolism, helping researchers understand its role in various biological processes and its implications in health and disease.

Citations