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Catalog Number:
14295
CAS Number:
2022956-32-5
Nα-Fmoc-Nim-benzyl-D-histidine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-His(Bzl)-OH
Documents
$127.79 /250MG
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Product Information

Na-Fmoc-Nim-benzyl-D-histidine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which facilitates the selective coupling of amino acids during solid-phase peptide synthesis. Its unique structure, characterized by the benzyl and imidazole side chains, enhances the stability and bioactivity of peptides, making it an essential building block in the creation of bioactive compounds and pharmaceuticals. Researchers appreciate its ability to improve solubility and enhance the pharmacokinetic properties of peptides, which is crucial in the development of therapeutic agents.

In addition to its applications in peptide synthesis, Na-Fmoc-Nim-benzyl-D-histidine is also valuable in the study of protein interactions and enzyme activity. Its incorporation into peptide sequences can help elucidate mechanisms of action and improve the efficacy of peptide-based drugs. This compound stands out for its ability to provide researchers with a reliable tool for advancing their work in medicinal chemistry and biochemistry, ultimately contributing to the development of innovative therapeutic solutions.

Synonyms
Fmoc-D-His(Bzl)-OH
CAS Number
2022956-32-5
Purity
≥ 99% (HPLC)
Molecular Formula
C28H25N3O4
Molecular Weight
467.5
MDL Number
MFCD08458517
PubChem ID
100110
Appearance
White powder
Optical Rotation
[a]D24 = -111 ± 4º (C=1% in Chloroform)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-D-His(Bzl)-OH
CAS Number
2022956-32-5
Purity
≥ 99% (HPLC)
Molecular Formula
C28H25N3O4
Molecular Weight
467.5
MDL Number
MFCD08458517
PubChem ID
100110
Appearance
White powder
Optical Rotation
[a]D24 = -111 ± 4º (C=1% in Chloroform)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nim-benzyl-D-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in the development of therapeutic agents. Its protective Fmoc group allows for selective deprotection during synthesis, enhancing efficiency.
  • Drug Development: Researchers use this compound in the design of novel drugs that target specific biological pathways, especially in cancer and metabolic disorders, due to its unique structural properties.
  • Bioconjugation: The compound can be employed in bioconjugation processes, linking biomolecules to therapeutic agents, which improves drug delivery and efficacy in targeted therapies.
  • Protein Engineering: It plays a significant role in protein engineering, where it is used to modify proteins for improved stability and function, aiding in the development of biopharmaceuticals.
  • Diagnostics: Na-Fmoc-Nim-benzyl-D-histidine is also explored in diagnostic applications, particularly in the development of biosensors that detect specific biomolecules, enhancing disease detection capabilities.

Citations