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Catalog Number:
14044
CAS Number:
352523-16-1
Fmoc-L-Phe(2-trifluoromethyl)-OH
Purity:
≥ 99% (Assay)
Synonym(s):
Fmoc-L-Phe(2-CF3)-OH, Fmoc-o-trifluoromethyl-L-phenylalanine, Fmoc-Phe(2-CF3)-OH
Documents
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Product Information

Fmoc-L-Phe(2-trifluoromethyl)-OH is a highly specialized amino acid derivative that serves as a vital building block in peptide synthesis and drug development. This compound features a unique trifluoromethyl group, enhancing its bioactivity and making it particularly valuable in medicinal chemistry. Its Fmoc (fluorenylmethyloxycarbonyl) protecting group allows for easy incorporation into peptide chains, facilitating the synthesis of complex peptides with improved stability and solubility. Researchers and industry professionals utilize this compound in the development of pharmaceuticals, particularly in creating targeted therapies and biologically active peptides.

The trifluoromethyl substitution not only contributes to the compound's lipophilicity but also enhances its interaction with biological targets, making it an attractive option for drug design. Its applications extend to the fields of biochemistry and molecular biology, where it is employed in the synthesis of peptide-based drugs and research into protein interactions. By incorporating Fmoc-L-Phe(2-trifluoromethyl)-OH into their workflows, scientists can achieve greater efficiency and specificity in their research and development efforts.

Synonyms
Fmoc-L-Phe(2-CF3)-OH, Fmoc-o-trifluoromethyl-L-phenylalanine, Fmoc-Phe(2-CF3)-OH
CAS Number
352523-16-1
Purity
≥ 99% (Assay)
Molecular Formula
C25H20F3NO4
Molecular Weight
455.43
MDL Number
MFCD01863052
PubChem ID
4223809
Melting Point
148 - 176 ?C (Lit.)
Appearance
White to almost white solid
Optical Rotation
[a]D20 = -42 ± 2 ° (Lit.)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Phe(2-CF3)-OH, Fmoc-o-trifluoromethyl-L-phenylalanine, Fmoc-Phe(2-CF3)-OH
CAS Number
352523-16-1
Purity
≥ 99% (Assay)
Molecular Formula
C25H20F3NO4
Molecular Weight
455.43
MDL Number
MFCD01863052
PubChem ID
4223809
Melting Point
148 - 176 ?C (Lit.)
Appearance
White to almost white solid
Optical Rotation
[a]D20 = -42 ± 2 ° (Lit.)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-Phe(2-trifluoromethyl)-OH is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in solid-phase peptide synthesis, allowing researchers to create complex peptides with high purity and yield.
  • Drug Development: Its unique trifluoromethyl group enhances the pharmacological properties of peptides, making it valuable in the design of new therapeutic agents.
  • Bioconjugation: The chemical's functional groups facilitate bioconjugation processes, enabling the attachment of peptides to various biomolecules for targeted drug delivery systems.
  • Research in Cancer Therapy: Its application in developing peptide-based drugs shows promise in targeting cancer cells more effectively, potentially leading to improved treatment outcomes.
  • Material Science: The compound can be used in creating advanced materials with specific properties, such as increased stability and enhanced interactions with biological systems.

Citations