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Catalog Number:
12395
CAS Number:
174080-12-7
Nα-Fmoc-D-tryptophan N-hydroxysuccinimide ester
Purity:
≥ 97% (HPLC)
Synonym(s):
Fmoc-D-Trp-OSu
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Product Information

Na-Fmoc-D-tryptophan N-hydroxysuccinimide ester is a versatile compound widely utilized in peptide synthesis and drug development. This amino acid derivative features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block for researchers in the field of medicinal chemistry. Its unique structure enhances the stability and solubility of peptides, facilitating the development of complex biomolecules.

This compound is particularly valuable in the synthesis of peptide-based therapeutics, where precise control over amino acid sequences is crucial. Researchers can leverage its properties to create targeted drug delivery systems or to explore novel therapeutic pathways. Additionally, Na-Fmoc-D-tryptophan N-hydroxysuccinimide ester can be employed in the study of protein interactions and enzyme activities, providing insights that are vital for advancing biochemistry and pharmacology. Its ability to streamline peptide synthesis while maintaining high purity levels makes it a preferred choice among professionals in the industry.

Synonyms
Fmoc-D-Trp-OSu
CAS Number
174080-12-7
Purity
≥ 97% (HPLC)
Molecular Formula
C30H25N3O6
Molecular Weight
523.5
MDL Number
MFCD01076144
PubChem ID
74765177
Melting Point
103-107 °C (dec.)
Appearance
Yellow powder
Optical Rotation
[α]D20 = +22 ± 2º (C=1% in Dioxane)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-D-Trp-OSu
CAS Number
174080-12-7
Purity
≥ 97% (HPLC)
Molecular Formula
C30H25N3O6
Molecular Weight
523.5
MDL Number
MFCD01076144
PubChem ID
74765177
Melting Point
103-107 °C (dec.)
Appearance
Yellow powder
Optical Rotation
[α]D20 = +22 ± 2º (C=1% in Dioxane)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-D-tryptophan N-hydroxysuccinimide ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly for creating complex sequences that include D-tryptophan. Its use enhances the efficiency of solid-phase peptide synthesis, allowing for the production of high-purity peptides.
  • Drug Development: In pharmaceutical research, it is employed to develop novel drug candidates that target specific biological pathways. Its ability to modify the structure of peptides can lead to improved pharmacokinetic properties.
  • Bioconjugation: The N-hydroxysuccinimide ester functionality allows for easy conjugation with various biomolecules, facilitating the creation of targeted drug delivery systems and diagnostic agents in biomedicine.
  • Research in Neuroscience: This compound is used in studies related to neurotransmitter pathways, particularly those involving tryptophan derivatives, which are crucial for understanding mood regulation and mental health.
  • Protein Engineering: It plays a role in modifying proteins to enhance their stability and activity, making it valuable in the development of enzyme inhibitors and therapeutic proteins.

Citations