Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
11962
CAS Number:
145038-50-2
Fmoc-L-glutamic acid γ-methyl ester
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Glu(OMe)-OH, Fmoc-L-glutamic acid 5-methyl ester
Documents
$19.73 /1G
Pack Size Availability Price
Request Bulk Quote
Product Information

Fmoc-L-glutamic acid g-methyl ester is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block in the production of complex peptides. Its unique structure not only enhances solubility but also improves stability, making it suitable for various applications in pharmaceutical research and biochemistry. Researchers often leverage this compound for its ability to facilitate the formation of peptide bonds, thereby streamlining the synthesis of bioactive peptides and proteins.

In addition to its role in peptide synthesis, Fmoc-L-glutamic acid g-methyl ester is also employed in the development of targeted drug delivery systems and in the study of protein interactions. Its compatibility with solid-phase peptide synthesis (SPPS) techniques allows for efficient and high-yield production of peptides, which are crucial in therapeutic applications. The compound's favorable properties, including its ease of handling and purification, make it a preferred choice for researchers and industry professionals looking to advance their work in peptide chemistry and drug formulation.

Synonyms
Fmoc-L-Glu(OMe)-OH, Fmoc-L-glutamic acid 5-methyl ester
CAS Number
145038-50-2
Purity
≥ 98% (HPLC)
Molecular Formula
C21H21NO6
Molecular Weight
383.36
MDL Number
MFCD01076132
PubChem ID
72493182
Melting Point
110 - 120 °C
Appearance
White powder
Optical Rotation
[a]D20 = -10 ± 2 ° (C=2 in MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Glu(OMe)-OH, Fmoc-L-glutamic acid 5-methyl ester
CAS Number
145038-50-2
Purity
≥ 98% (HPLC)
Molecular Formula
C21H21NO6
Molecular Weight
383.36
MDL Number
MFCD01076132
PubChem ID
72493182
Melting Point
110 - 120 °C
Appearance
White powder
Optical Rotation
[a]D20 = -10 ± 2 ° (C=2 in MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-glutamic acid g-methyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides. Its protective Fmoc group allows for selective deprotection, facilitating the assembly of complex peptide chains.
  • Drug Development: In pharmaceutical research, it is used to create peptide-based drugs. Its unique structure can enhance the bioavailability and stability of therapeutic peptides.
  • Bioconjugation: This chemical is employed in bioconjugation processes, linking peptides to other molecules like antibodies or drugs, which is crucial for targeted therapy in cancer treatment.
  • Research in Neuroscience: It plays a role in studying neurotransmitter functions due to its glutamic acid component, aiding researchers in understanding synaptic transmission and neuropharmacology.
  • Protein Engineering: The compound is useful in modifying proteins to improve their properties, such as solubility and stability, which is essential in various biotechnological applications.

Citations