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Catalog Number:
11631
CAS Number:
252049-16-4
Fmoc-His(3-Me)-OH
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-His(π-Me)-OH, Fmoc-N-π-methyl-L-histidine
Documents
$95.00 /100MG
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Product Information

Fmoc-His(3-Me)-OH is a versatile amino acid derivative widely utilized in peptide synthesis and research applications. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during solid-phase peptide synthesis. Its unique structure, incorporating a 3-methylimidazole side chain, enhances its compatibility in various biochemical applications, making it an excellent choice for researchers focusing on peptide-based drug development and protein engineering.

The compound's stability under standard laboratory conditions and its ease of incorporation into peptides make it a preferred choice for synthesizing complex biomolecules. Fmoc-His(3-Me)-OH can be effectively used in the development of therapeutic peptides, particularly those targeting specific biological pathways or exhibiting enhanced bioactivity. Its ability to facilitate the introduction of histidine residues into peptide sequences allows for the exploration of metal-binding properties and catalytic functions, which are crucial in many biochemical processes.

Synonyms
Fmoc-L-His(π-Me)-OH, Fmoc-N-π-methyl-L-histidine
CAS Number
252049-16-4
Purity
≥ 98% (HPLC)
Molecular Formula
C22H21N3O4
Molecular Weight
391.43
MDL Number
MFCD02259494
PubChem ID
78437533
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -5 ± 2 ° (C=1 in 2N HCl)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-His(π-Me)-OH, Fmoc-N-π-methyl-L-histidine
CAS Number
252049-16-4
Purity
≥ 98% (HPLC)
Molecular Formula
C22H21N3O4
Molecular Weight
391.43
MDL Number
MFCD02259494
PubChem ID
78437533
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -5 ± 2 ° (C=1 in 2N HCl)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-His(3-Me)-OH is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in solid-phase peptide synthesis, allowing for the selective addition of amino acids while preventing unwanted reactions.
  • Drug Development: Its role in modifying peptide structures can enhance the bioactivity and stability of therapeutic peptides, making it valuable in pharmaceutical research.
  • Bioconjugation: Fmoc-His(3-Me)-OH is used to create conjugates with biomolecules, facilitating targeted drug delivery systems in cancer therapy.
  • Protein Engineering: Researchers utilize this compound to introduce specific histidine residues in proteins, which can improve their binding properties and catalytic activities.
  • Analytical Chemistry: It aids in the development of analytical methods for detecting and quantifying peptides, contributing to advancements in proteomics.

Citations