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Catalog Number:
11336
CAS Number:
200871-84-7
Boc-D-His(3-Me)-OH
Purity:
≥ 99% (TLC)
Synonym(s):
Boc-D-His(π-Me)-OH, Boc-N-π-methyl-D-histidine
Documents
$95.00 /25MG
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Product Information

Boc-D-His(3-Me)-OH is a valuable amino acid derivative widely utilized in peptide synthesis and pharmaceutical research. This compound features a protected histidine residue, making it an essential building block for the development of bioactive peptides and proteins. Its unique structure, characterized by the presence of a tert-butoxycarbonyl (Boc) protecting group, allows for selective reactions, enhancing the efficiency of synthetic pathways. Researchers appreciate its stability and compatibility with various coupling reagents, which facilitates the formation of complex peptide sequences.

In the pharmaceutical industry, Boc-D-His(3-Me)-OH is particularly relevant for the design of therapeutic peptides that target specific biological pathways. Its application extends to the development of drug candidates with improved efficacy and reduced side effects. Additionally, this compound is instrumental in the study of histidine's role in enzyme catalysis and protein interactions, providing insights that can lead to innovative therapeutic strategies. With its robust properties and versatility, Boc-D-His(3-Me)-OH stands out as a crucial tool for researchers and industry professionals alike.

Synonyms
Boc-D-His(π-Me)-OH, Boc-N-π-methyl-D-histidine
CAS Number
200871-84-7
Purity
≥ 99% (TLC)
Molecular Formula
C12H19N3O4
Molecular Weight
269.3
MDL Number
MFCD00237545
PubChem ID
18510577
Melting Point
176 - 184 °C
Appearance
White powder
Optical Rotation
[a]D24 = -24.6 ± 2 º (C=1% in MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Boc-D-His(π-Me)-OH, Boc-N-π-methyl-D-histidine
CAS Number
200871-84-7
Purity
≥ 99% (TLC)
Molecular Formula
C12H19N3O4
Molecular Weight
269.3
MDL Number
MFCD00237545
PubChem ID
18510577
Melting Point
176 - 184 °C
Appearance
White powder
Optical Rotation
[a]D24 = -24.6 ± 2 º (C=1% in MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Boc-D-His(3-Me)-OH is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in the development of therapeutic proteins and biologics. Its protective Boc group allows for selective reactions, enhancing the efficiency of peptide assembly.
  • Drug Development: In medicinal chemistry, it plays a crucial role in designing new drug candidates, especially those targeting histidine residues in proteins, which are vital for enzyme activity and receptor binding.
  • Bioconjugation: The compound is used in bioconjugation processes, facilitating the attachment of biomolecules to drugs or imaging agents, which can improve drug delivery and efficacy in targeted therapies.
  • Protein Engineering: Researchers leverage Boc-D-His(3-Me)-OH in protein engineering to modify histidine residues, enhancing protein stability and functionality, which is essential in biopharmaceutical applications.
  • Analytical Chemistry: It is utilized in analytical methods for the detection and quantification of histidine-containing compounds, aiding in quality control and research in food and pharmaceutical industries.

Citations