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Catalog Number:
10100
CAS Number:
51077-01-1
Tosyl-L-proline
Purity:
≥ 99% (TLC)
Synonym(s):
Tos-L-Pro-OH, (2S-1-[(4-Methylphenyl)sulfonyl]pyrrolidine-2-carboxylicacid
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Product Information

Tosyl-L-proline is a versatile compound widely recognized for its applications in organic synthesis and pharmaceutical development. This sulfonamide derivative of proline features a tosyl group, enhancing its reactivity and making it an essential building block in the synthesis of various bioactive molecules. Its unique structure allows for the formation of peptide bonds, which is particularly valuable in the development of peptide-based therapeutics. Researchers utilize Tosyl-L-proline in asymmetric synthesis, where it serves as a chiral auxiliary, facilitating the production of enantiomerically pure compounds.

In addition to its role in synthetic chemistry, Tosyl-L-proline is also employed in the preparation of ligands for metal-catalyzed reactions, showcasing its versatility in catalysis. Its stability and ease of handling make it a preferred choice among chemists looking to streamline their synthesis processes. With its proven track record in enhancing reaction efficiency and selectivity, Tosyl-L-proline stands out as a crucial reagent for researchers and industry professionals aiming to innovate in drug discovery and development.

Synonyms
Tos-L-Pro-OH, (2S-1-[(4-Methylphenyl)sulfonyl]pyrrolidine-2-carboxylicacid
CAS Number
51077-01-1
Purity
≥ 99% (TLC)
Molecular Formula
C12H15NO4S
Molecular Weight
269.32
MDL Number
MFCD00238392
PubChem ID
563461
Melting Point
57 - 59 °C
Appearance
White powder
Optical Rotation
[a]D24 2O + 2 Aq. NaOH 1N)
Conditions
Store at RT
General Information
Synonyms
Tos-L-Pro-OH, (2S-1-[(4-Methylphenyl)sulfonyl]pyrrolidine-2-carboxylicacid
CAS Number
51077-01-1
Purity
≥ 99% (TLC)
Molecular Formula
C12H15NO4S
Molecular Weight
269.32
MDL Number
MFCD00238392
PubChem ID
563461
Melting Point
57 - 59 °C
Appearance
White powder
Optical Rotation
[a]D24 2O + 2 Aq. NaOH 1N)
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Tosyl-L-proline is widely utilized in research focused on:

  • Peptide Synthesis: It serves as a valuable building block in the synthesis of peptides, enhancing the efficiency and selectivity of reactions.
  • Drug Development: This compound is used in medicinal chemistry to develop new pharmaceuticals, particularly in creating compounds with improved bioactivity.
  • Asymmetric Synthesis: Tosyl-L-proline is instrumental in asymmetric synthesis, allowing researchers to produce chiral molecules with high enantioselectivity.
  • Catalysis: It acts as a catalyst in various organic reactions, providing advantages in reaction rates and yields compared to traditional catalysts.
  • Biochemical Research: This compound is employed in biochemical studies to investigate enzyme mechanisms and protein interactions, offering insights into biological processes.

Citations