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Catalog Number:
07403
CAS Number:
220497-79-0
Fmoc-2-bromo-D-phenylalanine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-Phe(2-Br)-OH, Fmoc-o-bromo-D-Phe-OH, (R-Fmoc-2-amino-3-(2-bromophenyl)propionic acid
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Product Information

Fmoc-2-bromo-D-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which allows for selective deprotection during the synthesis process, making it an essential building block for the creation of complex peptides. Its bromine substituent enhances the reactivity of the phenylalanine side chain, facilitating the introduction of various functional groups, which is particularly beneficial in medicinal chemistry and the development of novel therapeutics.

Researchers in the fields of biochemistry and pharmaceutical sciences appreciate the compound's ability to improve the stability and bioactivity of peptides. Fmoc-2-bromo-D-phenylalanine has been effectively employed in the synthesis of peptide-based drugs and in the study of protein interactions, showcasing its relevance in both academic research and industrial applications. Its unique properties not only streamline the synthesis process but also enhance the overall efficacy of peptide-based compounds, making it a valuable asset for professionals seeking innovative solutions in peptide chemistry.

Synonyms
Fmoc-D-Phe(2-Br)-OH, Fmoc-o-bromo-D-Phe-OH, (R-Fmoc-2-amino-3-(2-bromophenyl)propionic acid
CAS Number
220497-79-0
Purity
≥ 99% (HPLC)
Molecular Formula
C24H20BrNO4
Molecular Weight
466.3
MDL Number
MFCD01311770
PubChem ID
44181941
Melting Point
150 - 162 ?C
Optical Rotation
[a]20D = 64 ± 1 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Phe(2-Br)-OH, Fmoc-o-bromo-D-Phe-OH, (R-Fmoc-2-amino-3-(2-bromophenyl)propionic acid
CAS Number
220497-79-0
Purity
≥ 99% (HPLC)
Molecular Formula
C24H20BrNO4
Molecular Weight
466.3
MDL Number
MFCD01311770
PubChem ID
44181941
Melting Point
150 - 162 ?C
Optical Rotation
[a]20D = 64 ± 1 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-2-bromo-D-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a crucial building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex and functional peptide sequences.
  • Drug Development: It plays a significant role in the pharmaceutical industry for developing novel therapeutic agents, especially in designing peptides that can target specific biological pathways.
  • Bioconjugation: Researchers use it for bioconjugation processes, linking peptides to other molecules, which enhances the efficacy of drug delivery systems and improves targeting in cancer therapies.
  • Research in Neuroscience: This compound is valuable in neuroscience research, particularly in studying neuropeptides and their roles in neurotransmission, providing insights into brain function and disorders.
  • Protein Engineering: It is employed in protein engineering applications, where modifications to amino acids can lead to improved stability and functionality of proteins, benefiting various biotechnological applications.

Citations