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Catalog Number:
07402
CAS Number:
220497-47-2
Fmoc-2-bromo-L-phenylalanine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Phe(2-Br)-OH, Fmoc-o-bromo-L-Phe-OH, Fmoc-Phe(2-Br)-OH
Documents
$72.31 /1G
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Product Information

Fmoc-2-bromo-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which facilitates the selective modification of amino acids during solid-phase peptide synthesis. Its bromine substitution on the phenyl ring enhances its reactivity, making it an excellent choice for introducing specific functionalities into peptides. Researchers and industry professionals appreciate its ability to streamline the synthesis of complex peptides, particularly in the fields of medicinal chemistry and biochemistry.

The practical applications of Fmoc-2-bromo-L-phenylalanine extend to the development of peptide-based therapeutics and the study of protein interactions. Its unique properties allow for the incorporation of bromo groups, which can be utilized in further chemical transformations, such as cross-coupling reactions. This compound is especially valuable for those looking to create novel peptide sequences with enhanced biological activity or specificity. With its robust performance in peptide synthesis, Fmoc-2-bromo-L-phenylalanine stands out as a critical tool for researchers aiming to innovate in drug design and development.

Synonyms
Fmoc-L-Phe(2-Br)-OH, Fmoc-o-bromo-L-Phe-OH, Fmoc-Phe(2-Br)-OH
CAS Number
220497-47-2
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20BrNO4
Molecular Weight
466.3
MDL Number
MFCD01311743
PubChem ID
44181941
Melting Point
160 - 170 °C
Appearance
White powder
Optical Rotation
[a]D20 = -67 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Phe(2-Br)-OH, Fmoc-o-bromo-L-Phe-OH, Fmoc-Phe(2-Br)-OH
CAS Number
220497-47-2
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20BrNO4
Molecular Weight
466.3
MDL Number
MFCD01311743
PubChem ID
44181941
Melting Point
160 - 170 °C
Appearance
White powder
Optical Rotation
[a]D20 = -67 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-2-bromo-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound is a key building block in the synthesis of peptides, allowing researchers to create complex structures for drug development and biological studies.
  • Drug Discovery: Its unique properties enable the design of novel pharmaceutical agents, particularly in targeting specific biological pathways, enhancing the efficacy of drug candidates.
  • Bioconjugation: The chemical is used in bioconjugation processes, linking biomolecules to create targeted therapies, which is crucial in cancer treatment and diagnostics.
  • Protein Engineering: Researchers leverage its characteristics to modify proteins, improving their stability and functionality, which is essential in developing biopharmaceuticals.
  • Analytical Chemistry: It serves as a reagent in analytical methods, aiding in the detection and quantification of various compounds, thus supporting quality control in pharmaceutical manufacturing.

Citations