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Catalog Number:
07327
CAS Number:
185547-52-8
Fmoc-L-aspartic acid α-4-nitroanilide
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Asp-pNA
Documents
$72.31 /250MG
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Product Information

Fmoc-L-aspartic acid a-4-nitroanilide is a versatile compound widely utilized in peptide synthesis and drug development. This derivative of aspartic acid features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which enhances its stability and solubility, making it an ideal choice for solid-phase peptide synthesis. The presence of the 4-nitroanilide moiety not only contributes to its unique chemical properties but also allows for specific applications in the development of bioactive peptides and pharmaceuticals. Researchers appreciate its ability to facilitate the introduction of aspartic acid residues into peptides, which can be crucial for the design of therapeutic agents targeting various biological pathways.

In addition to its role in peptide synthesis, Fmoc-L-aspartic acid a-4-nitroanilide has potential applications in the fields of biochemistry and molecular biology, particularly in the study of enzyme mechanisms and protein interactions. Its unique structure allows for the exploration of aspartic acid's role in enzymatic activity and protein folding. This compound stands out among similar products due to its enhanced reactivity and compatibility with various coupling reagents, making it a preferred choice for researchers aiming to optimize their peptide synthesis processes.

Synonyms
Fmoc-L-Asp-pNA
CAS Number
185547-52-8
Purity
≥ 98% (HPLC)
Molecular Formula
C25H21N3O7
Molecular Weight
475.46
MDL Number
MFCD02179637
PubChem ID
4712541
Appearance
Off-white powder
Optical Rotation
[a]D20 = -40 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Asp-pNA
CAS Number
185547-52-8
Purity
≥ 98% (HPLC)
Molecular Formula
C25H21N3O7
Molecular Weight
475.46
MDL Number
MFCD02179637
PubChem ID
4712541
Appearance
Off-white powder
Optical Rotation
[a]D20 = -40 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-aspartic acid a-4-nitroanilide is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing researchers to create complex peptides with specific sequences.
  • Drug Development: It plays a significant role in medicinal chemistry, where it is used to design and develop new pharmaceutical compounds, particularly those targeting neurological disorders.
  • Fluorescent Probes: The compound can be modified to create fluorescent probes for biological imaging, enhancing the visualization of cellular processes in research and diagnostics.
  • Bioconjugation: It is employed in bioconjugation techniques, linking biomolecules to therapeutic agents or imaging agents, which is crucial in targeted drug delivery systems.
  • Research in Neuroscience: The compound is utilized in studies investigating neurotransmitter pathways and receptor interactions, contributing to the understanding of various neurological conditions.

Citations