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Catalog Number:
07110
CAS Number:
682800-84-6
Fmoc-O-trityl-D-threonine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Thr(Trt)-OH
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Product Information

Fmoc-O-trityl-D-threonine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an invaluable tool for researchers in the field of organic chemistry and biochemistry. Its trityl group enhances stability and solubility, facilitating the formation of complex peptides and proteins.

In practical applications, Fmoc-O-trityl-D-threonine is particularly beneficial in the synthesis of therapeutic peptides, where precise control over amino acid sequences is crucial. Its unique properties enable researchers to achieve higher yields and purities in their peptide products, which is essential for pharmaceutical applications. Additionally, this compound is recognized for its compatibility with various coupling reagents, making it a preferred choice for chemists looking to streamline their synthesis protocols. Overall, Fmoc-O-trityl-D-threonine stands out as a key reagent in the advancement of peptide chemistry and drug discovery.

Synonyms
Fmoc-D-Thr(Trt)-OH
CAS Number
682800-84-6
Purity
≥ 98% (HPLC)
Molecular Formula
C38H33NO5
Molecular Weight
583.7
MDL Number
MFCD01631661
PubChem ID
53394879
Melting Point
70-75 °C
Appearance
Off-white to brown crystals
Optical Rotation
[a]D20 = +25.5 ± 2º (C=1 in EtOAc)
Conditions
Store at ≤ -4 °C
General Information
Synonyms
Fmoc-D-Thr(Trt)-OH
CAS Number
682800-84-6
Purity
≥ 98% (HPLC)
Molecular Formula
C38H33NO5
Molecular Weight
583.7
MDL Number
MFCD01631661
PubChem ID
53394879
Melting Point
70-75 °C
Appearance
Off-white to brown crystals
Optical Rotation
[a]D20 = +25.5 ± 2º (C=1 in EtOAc)
Conditions
Store at ≤ -4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-trityl-D-threonine is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a protecting group in the synthesis of peptides, allowing for the selective modification of amino acids without interfering with other functional groups. This is particularly useful in the pharmaceutical industry for developing new drugs.
  • Bioconjugation: It is employed in bioconjugation techniques to attach biomolecules, such as proteins or nucleic acids, to surfaces or other molecules. This application is vital in the development of targeted therapies and diagnostics.
  • Research in Protein Engineering: Researchers use this compound to study protein folding and stability, which can lead to advancements in enzyme design and therapeutic proteins, enhancing drug efficacy.
  • Development of Antibody-Drug Conjugates: Fmoc-O-trityl-D-threonine is instrumental in creating antibody-drug conjugates, which are designed to deliver cytotoxic drugs directly to cancer cells, minimizing damage to healthy tissue.
  • Custom Synthesis Services: Companies specializing in custom peptide synthesis utilize this compound to provide tailored solutions for clients in academia and industry, ensuring high-quality and specific peptide sequences for research and therapeutic purposes.

Citations