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Catalog Number:
05976
CAS Number:
3398-22-9
trans-D-4-Hydroxyproline
Purity:
≥ 99% (HPLC)
Synonym(s):
D-Hyp-OH, (2R,4S-4-Hydroxypyrrolidine-2-carboxylic acid, H-D-Hyp-OH
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Product Information

trans-D-4-Hydroxyproline is a valuable amino acid derivative recognized for its unique structural properties and versatile applications in both research and industry. This compound, a stereoisomer of proline, is particularly significant in the synthesis of collagen and other proteins, making it essential in biomedical research and pharmaceutical formulations. Its hydroxyl group enhances its reactivity, allowing it to participate in various biochemical processes, including the stabilization of protein structures. Researchers often utilize trans-D-4-Hydroxyproline in studies related to tissue engineering, drug delivery systems, and the development of therapeutic agents aimed at treating fibrotic diseases.

In addition to its applications in biochemistry, trans-D-4-Hydroxyproline serves as a chiral building block in organic synthesis, facilitating the creation of complex molecules with high specificity. Its ability to improve the stability and solubility of formulations makes it a preferred choice in cosmetic and personal care products, where it contributes to skin hydration and elasticity. With its multifaceted roles, trans-D-4-Hydroxyproline stands out as a crucial compound for professionals seeking innovative solutions in health, beauty, and material sciences.

Synonyms
D-Hyp-OH, (2R,4S-4-Hydroxypyrrolidine-2-carboxylic acid, H-D-Hyp-OH
CAS Number
3398-22-9
Purity
≥ 99% (HPLC)
Molecular Formula
C5H9NO3
Molecular Weight
131.1
MDL Number
MFCD00065608
PubChem ID
825
Appearance
White to pale pink solid
Optical Rotation
[a]D22 = +76 ± 2º (C=1 in H2O)
Conditions
Store at 0-8 °C
General Information
Synonyms
D-Hyp-OH, (2R,4S-4-Hydroxypyrrolidine-2-carboxylic acid, H-D-Hyp-OH
CAS Number
3398-22-9
Purity
≥ 99% (HPLC)
Molecular Formula
C5H9NO3
Molecular Weight
131.1
MDL Number
MFCD00065608
PubChem ID
825
Appearance
White to pale pink solid
Optical Rotation
[a]D22 = +76 ± 2º (C=1 in H2O)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

trans-D-4-Hydroxyproline is widely utilized in research focused on:

  • Pharmaceutical Development: This compound is a key building block in the synthesis of various pharmaceuticals, particularly those targeting collagen-related disorders, enhancing drug efficacy and stability.
  • Protein Engineering: It is used to modify proteins, improving their stability and functionality. Researchers incorporate it into peptides to study its effects on protein folding and structure.
  • Cosmetic Formulations: The compound is incorporated into skincare products for its moisturizing properties and ability to promote skin elasticity, making it valuable in the beauty industry.
  • Biotechnology: In tissue engineering, it serves as a scaffold material, aiding in the development of biomaterials that support cell growth and tissue regeneration.
  • Food Industry: It is utilized as a food additive to enhance texture and nutritional value, particularly in protein-rich products, catering to health-conscious consumers.

Citations