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Catalog Number:
05721
CAS Number:
116611-64-4
Nα-Fmoc-L-histidine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-His-OH
Documents
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Product Information

Na-Fmoc-L-histidine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block for researchers in the fields of biochemistry and medicinal chemistry. Its unique structure not only enhances stability but also improves solubility in organic solvents, facilitating smoother reactions and higher yields in peptide formation.

In practical applications, Na-Fmoc-L-histidine is particularly valuable in the synthesis of histidine-containing peptides and proteins, which are crucial for various biological functions and therapeutic applications. Its role in the development of pharmaceuticals targeting histamine receptors and its potential in cancer research highlight its importance in modern drug discovery. Researchers benefit from its ease of use and the efficiency it brings to complex synthesis pathways, making Na-Fmoc-L-histidine a preferred choice for professionals aiming to innovate in peptide-based therapies.

Synonyms
Fmoc-L-His-OH
CAS Number
116611-64-4
Purity
≥ 98% (HPLC)
Molecular Formula
C21H19N3O4
Molecular Weight
377.4
MDL Number
MFCD00190885
PubChem ID
13577227
Appearance
White solid
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-L-His-OH
CAS Number
116611-64-4
Purity
≥ 98% (HPLC)
Molecular Formula
C21H19N3O4
Molecular Weight
377.4
MDL Number
MFCD00190885
PubChem ID
13577227
Appearance
White solid
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-L-histidine is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for the selective modification of amino acids. Its stability under various conditions makes it a preferred choice for researchers in organic chemistry.
  • Drug Development: In pharmaceutical research, it plays a critical role in the design of histidine-containing compounds, which are essential for developing new drugs targeting various diseases, including cancer and metabolic disorders.
  • Bioconjugation: Na-Fmoc-L-histidine is used in bioconjugation processes, where it helps in attaching biomolecules to surfaces or other molecules, enhancing the efficacy of drug delivery systems.
  • Protein Engineering: This compound is valuable in protein engineering, allowing scientists to modify proteins at specific sites, which can lead to the development of proteins with improved stability and activity.
  • Research on Enzyme Activity: It aids in studying enzyme mechanisms by providing a histidine residue that can participate in catalytic processes, helping researchers understand enzyme function and develop inhibitors.

Citations