Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
05719
CAS Number:
81379-52-4
Nα-Fmoc-Nim-Boc-L-histidine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-His(Boc)-OH
Documents
$35.00 /1G
Pack Size Availability Price
Request Bulk Quote
Product Information

Na-Fmoc-Nim-Boc-L-histidine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique combination of protective groups, including the Fmoc (9-fluorenylmethoxycarbonyl) and Boc (tert-butyloxycarbonyl) groups, which facilitate selective reactions and enhance stability during synthesis. Its structure allows for efficient incorporation into peptides, making it an essential building block for researchers working in medicinal chemistry and biochemistry.

The applications of Na-Fmoc-Nim-Boc-L-histidine extend to the development of peptide-based therapeutics, where its imidazole side chain can participate in various biochemical interactions. This compound is particularly valuable in the synthesis of histidine-containing peptides, which are known for their roles in enzyme catalysis and metal ion coordination. Researchers appreciate its ability to streamline the synthesis process while maintaining high purity and yield, making it a preferred choice for both academic and industrial applications.

Synonyms
Fmoc-L-His(Boc)-OH
CAS Number
81379-52-4
Purity
≥ 98% (HPLC)
Molecular Formula
C26H27N3O6
Molecular Weight
477.5
MDL Number
MFCD00151928
PubChem ID
4255658
Melting Point
110 - 135 ?C (Lit.)
Appearance
White to off-white powder
Optical Rotation
[a]20D = -7 ± 2.5 ° (C=1 in DMF)
Conditions
Store at ≤ - 15 °C
General Information
Synonyms
Fmoc-L-His(Boc)-OH
CAS Number
81379-52-4
Purity
≥ 98% (HPLC)
Molecular Formula
C26H27N3O6
Molecular Weight
477.5
MDL Number
MFCD00151928
PubChem ID
4255658
Melting Point
110 - 135 ?C (Lit.)
Appearance
White to off-white powder
Optical Rotation
[a]20D = -7 ± 2.5 ° (C=1 in DMF)
Conditions
Store at ≤ - 15 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nim-Boc-L-histidine is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing researchers to create complex peptide sequences efficiently.
  • Drug Development: It is used in the development of pharmaceuticals, especially in designing histidine-containing compounds that can act as enzyme inhibitors or modulators, which are crucial in treating various diseases.
  • Bioconjugation: The chemical is valuable in bioconjugation techniques, where it helps in attaching biomolecules to surfaces or other molecules, enhancing the functionality of drugs and diagnostics.
  • Protein Engineering: It plays a significant role in protein engineering, aiding in the modification of proteins to improve their stability and activity, which is essential in biotechnology applications.
  • Research in Cancer Therapeutics: The compound is explored in cancer research for its potential to create targeted therapies, leveraging its ability to interact with specific biological targets in cancer cells.

Citations