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Catalog Number:
05710
CAS Number:
1301706-86-4
Fmoc-O-methyl-D-threonine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-Thr(Me)-OH
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Product Information

Fmoc-O-methyl-D-threonine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which facilitates the selective coupling of amino acids during solid-phase peptide synthesis. Its unique structure not only enhances the stability of the peptide chain but also allows for easy removal of the protecting group under mild conditions, making it an ideal choice for researchers aiming to create complex peptides with high purity and yield.

In addition to its role in peptide synthesis, Fmoc-O-methyl-D-threonine has shown potential in the development of therapeutic agents, particularly in the fields of pharmaceuticals and biotechnology. Its application extends to the synthesis of bioactive peptides, which are crucial for various biological functions and therapeutic interventions. Researchers can leverage this compound to explore new avenues in drug discovery and development, benefiting from its efficient coupling properties and the ability to introduce methylation at the threonine position, which can enhance the biological activity of the resulting peptides.

Synonyms
Fmoc-D-Thr(Me)-OH
CAS Number
1301706-86-4
Purity
≥ 99% (HPLC)
Molecular Formula
C20H21NO5
Molecular Weight
355.5
MDL Number
MFCD01632052
PubChem ID
46737426
Melting Point
148-154? C
Optical Rotation
+10.50º ± 1º (c=1.010% in DMF)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-D-Thr(Me)-OH
CAS Number
1301706-86-4
Purity
≥ 99% (HPLC)
Molecular Formula
C20H21NO5
Molecular Weight
355.5
MDL Number
MFCD01632052
PubChem ID
46737426
Melting Point
148-154? C
Optical Rotation
+10.50º ± 1º (c=1.010% in DMF)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-methyl-D-threonine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for the selective modification of amino acids without interfering with other functional groups. Its stability under various reaction conditions makes it a preferred choice for researchers.
  • Drug Development: In pharmaceutical research, it is used to create modified peptides that can enhance drug efficacy and stability. The incorporation of this compound can lead to improved bioavailability of therapeutic agents.
  • Bioconjugation: Fmoc-O-methyl-D-threonine can be employed in bioconjugation techniques to attach biomolecules to surfaces or other molecules, which is crucial in developing biosensors and targeted drug delivery systems.
  • Protein Engineering: This chemical is valuable in the field of protein engineering, where it aids in the design of proteins with enhanced properties, such as increased solubility or altered binding affinities, which are essential for various applications in biotechnology.
  • Research in Structural Biology: It is used in the study of protein structures and interactions, helping researchers understand the role of specific amino acids in protein function, which can lead to breakthroughs in understanding diseases at the molecular level.

Citations