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Catalog Number:
05708
CAS Number:
131545-63-6
Fmoc-O-benzyl-D-threonine
Purity:
≥ 97% (HPLC)
Synonym(s):
Fmoc-D-Thr(Bzl)-OH
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Product Information

Fmoc-O-benzyl-D-threonine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which is crucial for the selective protection of amino groups during the synthesis of complex peptides. Its unique structure allows for the introduction of a benzyl group, enhancing its stability and solubility in organic solvents, making it an ideal choice for researchers in the fields of medicinal chemistry and biochemistry.

In practical applications, Fmoc-O-benzyl-D-threonine is particularly valuable in the synthesis of bioactive peptides and pharmaceuticals, where precise control over amino acid sequences is essential. Its ability to facilitate the formation of peptide bonds while maintaining the integrity of the threonine side chain opens up possibilities for creating novel therapeutic agents. Researchers appreciate its compatibility with various coupling reagents and its efficiency in solid-phase peptide synthesis, making it a preferred choice for those looking to streamline their synthesis processes and achieve high yields.

Synonyms
Fmoc-D-Thr(Bzl)-OH
CAS Number
131545-63-6
Purity
≥ 97% (HPLC)
Molecular Formula
C26H25NO5
Molecular Weight
431.5
MDL Number
MFCD00237033
PubChem ID
4446312
Melting Point
105-113? C
Optical Rotation
-11.50º ± 1º (c=1 in MeOH)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-D-Thr(Bzl)-OH
CAS Number
131545-63-6
Purity
≥ 97% (HPLC)
Molecular Formula
C26H25NO5
Molecular Weight
431.5
MDL Number
MFCD00237033
PubChem ID
4446312
Melting Point
105-113? C
Optical Rotation
-11.50º ± 1º (c=1 in MeOH)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-benzyl-D-threonine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for selective reactions and improving yield and purity in complex sequences.
  • Drug Development: It plays a role in the design of peptide-based pharmaceuticals, particularly in creating more stable and effective drug candidates for various therapeutic areas.
  • Bioconjugation: The compound is used in bioconjugation processes, facilitating the attachment of biomolecules to surfaces or other molecules, which is crucial in diagnostics and targeted therapies.
  • Research in Protein Engineering: Its application in the modification of amino acids aids researchers in studying protein structure and function, enhancing our understanding of biological processes.
  • Custom Synthesis Services: Many companies offer custom synthesis of this compound, catering to specific research needs, which provides flexibility and tailored solutions for scientists.

Citations