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Catalog Number:
05085
CAS Number:
198544-60-4
Fmoc-D-leucyl chloride
Purity:
≥ 99%
Synonym(s):
Fmoc-D-Leu-Cl
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Product Information

Fmoc-D-leucyl chloride is a versatile reagent widely utilized in peptide synthesis and drug development. This compound serves as a key building block for the introduction of the Fmoc (9-fluorenylmethyloxycarbonyl) protecting group, which is essential for the selective protection of amino acids during solid-phase peptide synthesis. Its unique structure allows for efficient coupling reactions, making it an ideal choice for researchers looking to streamline their synthesis processes. The compound's stability and reactivity under various conditions enhance its applicability in both academic and industrial settings, particularly in the development of therapeutic peptides and complex biomolecules.

In addition to its role in peptide synthesis, Fmoc-D-leucyl chloride is also valuable in the modification of existing peptides to improve their pharmacological properties. Its ability to facilitate the introduction of functional groups can lead to enhanced bioactivity and specificity, making it a crucial tool in medicinal chemistry. Researchers and industry professionals can leverage this compound to create innovative solutions in drug design, ultimately contributing to advancements in healthcare and therapeutic interventions.

Synonyms
Fmoc-D-Leu-Cl
CAS Number
198544-60-4
Purity
≥ 99%
Molecular Formula
C21H22NO3Cl
Molecular Weight
371.8
MDL Number
MFCD00235819
PubChem ID
14482308
Melting Point
81 - 83 °C (dec.)
Appearance
White powder
Optical Rotation
[a]20D = 2 ± 1 º (C=1 in DCM)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Leu-Cl
CAS Number
198544-60-4
Purity
≥ 99%
Molecular Formula
C21H22NO3Cl
Molecular Weight
371.8
MDL Number
MFCD00235819
PubChem ID
14482308
Melting Point
81 - 83 °C (dec.)
Appearance
White powder
Optical Rotation
[a]20D = 2 ± 1 º (C=1 in DCM)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-D-leucyl chloride is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as an important building block in the synthesis of peptides, allowing researchers to create specific sequences for biological studies.
  • Drug Development: It plays a crucial role in the pharmaceutical industry for the development of peptide-based drugs, enhancing the efficacy and specificity of therapeutic agents.
  • Bioconjugation: Fmoc-D-leucyl chloride is used in bioconjugation processes, enabling the attachment of biomolecules to surfaces or other compounds, which is vital for creating targeted drug delivery systems.
  • Research in Protein Engineering: This chemical is instrumental in modifying proteins to study their functions, providing insights into enzyme activity and protein interactions.
  • Analytical Chemistry: It is employed in analytical techniques to improve the resolution and detection of peptides in complex mixtures, aiding in quality control and research applications.

Citations