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Catalog Number:
04139
CAS Number:
198545-46-9
Fmoc-2-fluoro-D-phenylalanine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-D-Phe(2-F)-OH, Fmoc-o-fluoro-D-Phe-OH
Documents
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Product Information

Fmoc-2-fluoro-D-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which facilitates the selective modification of amino acids during solid-phase peptide synthesis. The presence of the fluorine atom enhances its bioactivity and stability, making it an attractive choice for researchers focused on developing novel therapeutics. Its unique structure allows for improved binding affinity in peptide interactions, which is crucial in the design of peptide-based drugs and biomolecules.

In practical applications, Fmoc-2-fluoro-D-phenylalanine is employed in the synthesis of peptides that exhibit enhanced pharmacological properties, particularly in the fields of medicinal chemistry and biochemistry. Researchers have leveraged this compound to create peptides with specific biological activities, paving the way for advancements in targeted therapies and drug discovery. Its ability to improve the efficacy of peptide drugs sets it apart from similar compounds, making it a valuable asset in both academic and industrial research settings.

Synonyms
Fmoc-D-Phe(2-F)-OH, Fmoc-o-fluoro-D-Phe-OH
CAS Number
198545-46-9
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C24H20FNO4
Molecular Weight
405.4
MDL Number
MFCD00672553
PubChem ID
2759190
Appearance
White to off-white solid
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Phe(2-F)-OH, Fmoc-o-fluoro-D-Phe-OH
CAS Number
198545-46-9
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C24H20FNO4
Molecular Weight
405.4
MDL Number
MFCD00672553
PubChem ID
2759190
Appearance
White to off-white solid
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-2-fluoro-D-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This chemical is a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS). Its protective group allows for selective reactions, making it easier to assemble complex peptides.
  • Drug Development: The incorporation of fluorine in drug candidates can enhance their pharmacological properties. This compound is used in the design of novel therapeutics, particularly in targeting specific biological pathways.
  • Bioconjugation: Fmoc-2-fluoro-D-phenylalanine can be employed in bioconjugation techniques, linking peptides to various biomolecules such as antibodies or enzymes, which is essential for developing targeted drug delivery systems.
  • Research in Neuroscience: This compound is valuable in studying neurotransmitter systems, as it can mimic natural amino acids, allowing researchers to explore the effects of modified peptides on neuronal activity.
  • Analytical Chemistry: Its unique properties make it useful in analytical applications, such as chromatography, where it can help in the separation and identification of complex mixtures in biological samples.

Citations