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Catalog Number:
04122
CAS Number:
198545-59-4
Fmoc-3,4-difluoro-D-phenylalanine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Phe(3,4-DiF)-OH, Fmoc-3,4-difluoro-D-Phe-OH
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Product Information

Fmoc-3,4-difluoro-D-phenylalanine is a specialized amino acid derivative that plays a crucial role in peptide synthesis and drug development. This compound is particularly valued for its unique fluorinated phenyl group, which enhances the stability and bioactivity of peptides. Researchers utilize Fmoc-3,4-difluoro-D-phenylalanine in the design of peptide-based therapeutics, where the incorporation of fluorine can improve pharmacokinetic properties and increase binding affinity to target receptors. Its application extends to the development of novel inhibitors and biologically active compounds, making it a vital tool in medicinal chemistry and biochemistry.

The compound's Fmoc (fluorenylmethyloxycarbonyl) protecting group allows for easy incorporation into solid-phase peptide synthesis, facilitating the creation of complex peptide sequences. This feature, combined with its fluorinated structure, provides a significant advantage over traditional amino acids, enabling researchers to explore new avenues in drug design and development. Fmoc-3,4-difluoro-D-phenylalanine is an essential asset for professionals aiming to innovate in the fields of pharmaceuticals and biotechnology.

Synonyms
Fmoc-D-Phe(3,4-DiF)-OH, Fmoc-3,4-difluoro-D-Phe-OH
CAS Number
198545-59-4
Purity
≥ 98% (HPLC)
Molecular Formula
C24H19F2NO4
Molecular Weight
423.4
MDL Number
MFCD00672551
PubChem ID
2759189
Melting Point
154-161 °C
Appearance
White crystalline powder
Optical Rotation
[a]D = +40 ± 2º (C=1 in DMF)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-D-Phe(3,4-DiF)-OH, Fmoc-3,4-difluoro-D-Phe-OH
CAS Number
198545-59-4
Purity
≥ 98% (HPLC)
Molecular Formula
C24H19F2NO4
Molecular Weight
423.4
MDL Number
MFCD00672551
PubChem ID
2759189
Melting Point
154-161 °C
Appearance
White crystalline powder
Optical Rotation
[a]D = +40 ± 2º (C=1 in DMF)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-3,4-difluoro-D-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, where its protective Fmoc group allows for selective deprotection and coupling.
  • Drug Development: Its unique difluorophenyl group enhances the biological activity of peptides, making it valuable in the design of new pharmaceuticals targeting specific diseases.
  • Bioconjugation: The compound can be used in bioconjugation techniques to attach peptides to proteins or other biomolecules, facilitating the development of targeted therapies and diagnostics.
  • Research in Neuroscience: Due to its structural properties, it is often employed in studies related to neurotransmitter receptors, helping researchers understand receptor interactions and signaling pathways.
  • Fluorinated Compounds Research: Its incorporation of fluorine atoms allows for enhanced stability and bioavailability, making it a subject of interest in the study of fluorinated amino acids and their applications in medicinal chemistry.

Citations