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Catalog Number:
04109
CAS Number:
205526-37-0
Fmoc-3-cyano-D-phenylalanine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Phe(3-CN)-OH, Fmoc-m-cyano-D-Phe-OH
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Product Information

Fmoc-3-cyano-D-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which enhances its stability and facilitates the selective deprotection of amino acids during solid-phase peptide synthesis (SPPS). Its cyano group not only contributes to the compound's reactivity but also allows for the introduction of various functional groups, making it an invaluable building block in the creation of complex peptides and pharmaceuticals.

Researchers and industry professionals appreciate Fmoc-3-cyano-D-phenylalanine for its ability to enhance the solubility and bioavailability of peptides, which is crucial in drug formulation. Its application extends to the development of peptide-based therapeutics, where precise control over peptide structure is essential for achieving desired biological activity. With its favorable properties and functional versatility, this compound stands out as a key ingredient in the synthesis of innovative therapeutic agents and research applications.

Synonyms
Fmoc-D-Phe(3-CN)-OH, Fmoc-m-cyano-D-Phe-OH
CAS Number
205526-37-0
Purity
≥ 98% (HPLC)
Molecular Formula
C25H20N2O4
Molecular Weight
412.4
MDL Number
MFCD00797586
PubChem ID
4075330
Melting Point
111 - 113 ºC
Appearance
White powder
Optical Rotation
[a]20D = 36.5 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Phe(3-CN)-OH, Fmoc-m-cyano-D-Phe-OH
CAS Number
205526-37-0
Purity
≥ 98% (HPLC)
Molecular Formula
C25H20N2O4
Molecular Weight
412.4
MDL Number
MFCD00797586
PubChem ID
4075330
Melting Point
111 - 113 ºC
Appearance
White powder
Optical Rotation
[a]20D = 36.5 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-3-cyano-D-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), enhancing the efficiency and yield of complex peptide chains.
  • Drug Development: Its unique structure allows for the incorporation of cyano groups, which can improve the biological activity of pharmaceutical compounds, making it valuable in the development of new drugs.
  • Bioconjugation: The compound can be used to create bioconjugates, linking peptides to various biomolecules, which is essential in the design of targeted therapies and diagnostics.
  • Research in Neuroscience: Fmoc-3-cyano-D-phenylalanine is utilized in studies related to neurotransmitter pathways, aiding in the understanding of neurological disorders and potential treatments.
  • Analytical Chemistry: It is employed in analytical techniques to study protein interactions and modifications, providing insights into protein function and structure.