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Catalog Number:
04038
CAS Number:
32926-43-5
Nα-Boc-Nim-trityl-L-histidine
Purity:
≥ 99.7% (HPLC, Chiral purity)
Synonym(s):
Boc-L-His(Trt)-OH
Documents
$36.65 /1G
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Product Information

Na-Boc-Nim-trityl-L-histidine is a versatile amino acid derivative that plays a crucial role in peptide synthesis and drug development. This compound features a unique Boc (tert-butyloxycarbonyl) protecting group, which enhances its stability and solubility, making it an excellent choice for researchers working on complex organic syntheses. Its trityl group provides additional protection for the imidazole side chain, allowing for selective reactions that are essential in the formation of biologically active peptides.

In the pharmaceutical industry, Na-Boc-Nim-trityl-L-histidine is particularly valuable for the synthesis of peptide-based therapeutics, where precise control over amino acid sequences is critical. Its application extends to the development of novel drug candidates, especially in the field of oncology and immunology, where histidine residues are often integral to the activity of therapeutic peptides. Researchers appreciate its ability to facilitate the formation of stable peptide bonds while maintaining the integrity of sensitive functional groups, thus streamlining the synthesis process and improving yield.

Synonyms
Boc-L-His(Trt)-OH
CAS Number
32926-43-5
Purity
≥ 99.7% (HPLC, Chiral purity)
Molecular Formula
C30H31N3O4
Molecular Weight
497.6
MDL Number
MFCD00153307
PubChem ID
3437537
Appearance
White to off white powder
Optical Rotation
[a]D20 = +12.0 ± 2º (C=1 in MeOH)
Conditions
Store at 0-8 °C
General Information
Synonyms
Boc-L-His(Trt)-OH
CAS Number
32926-43-5
Purity
≥ 99.7% (HPLC, Chiral purity)
Molecular Formula
C30H31N3O4
Molecular Weight
497.6
MDL Number
MFCD00153307
PubChem ID
3437537
Appearance
White to off white powder
Optical Rotation
[a]D20 = +12.0 ± 2º (C=1 in MeOH)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Boc-Nim-trityl-L-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group in the synthesis of peptides, allowing for selective reactions without unwanted side reactions. Its stability under various conditions makes it a preferred choice for researchers.
  • Drug Development: It plays a crucial role in the development of pharmaceutical compounds, particularly in designing histidine-containing drugs that can target specific biological pathways effectively.
  • Bioconjugation: The compound is used in bioconjugation processes, where it helps attach biomolecules to surfaces or other molecules, enhancing the functionality of drugs and diagnostic agents.
  • Research in Enzyme Activity: Researchers utilize it to study enzyme mechanisms and interactions, particularly those involving histidine residues, providing insights into enzyme function and regulation.
  • Protein Engineering: It aids in the modification of proteins to improve their stability and activity, which is essential in various biotechnological applications, including the development of biosensors and therapeutic proteins.

Citations