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Catalog Number:
03737
CAS Number:
111061-56-4
Fmoc-O-trityl-L-serine
Purity:
≥ 99.5% (HPLC, Chiral purity)
Synonym(s):
Fmoc-L-Ser(Trt)-OH
Documents
$22.83 /1G
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Product Information

Fmoc-O-trityl-L-serine is a highly versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block for the creation of complex peptides. Its trityl (Tr) protection enhances stability and solubility, facilitating its use in various organic reactions. Researchers and industry professionals appreciate its role in solid-phase peptide synthesis, where it enables the efficient assembly of peptides with high purity and yield.

In addition to its applications in peptide synthesis, Fmoc-O-trityl-L-serine is also valuable in the development of pharmaceuticals and bioconjugates. Its unique properties allow for the incorporation of serine residues into peptides, which can be crucial for biological activity and specificity. This compound stands out for its ability to streamline the synthesis process while maintaining the integrity of sensitive functional groups, making it a preferred choice for chemists and researchers in the field.

Synonyms
Fmoc-L-Ser(Trt)-OH
CAS Number
111061-56-4
Purity
≥ 99.5% (HPLC, Chiral purity)
Molecular Formula
C37H31NO5
Molecular Weight
569.7
MDL Number
MFCD00153364
PubChem ID
4219289
Melting Point
200-210 ºC
Appearance
White powder
Optical Rotation
[a]D20 = + 8 ± 1º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Ser(Trt)-OH
CAS Number
111061-56-4
Purity
≥ 99.5% (HPLC, Chiral purity)
Molecular Formula
C37H31NO5
Molecular Weight
569.7
MDL Number
MFCD00153364
PubChem ID
4219289
Melting Point
200-210 ºC
Appearance
White powder
Optical Rotation
[a]D20 = + 8 ± 1º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-trityl-L-serine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group for the amino acid serine during solid-phase peptide synthesis, allowing for the selective modification of peptides without unwanted reactions.
  • Drug Development: Its role in synthesizing bioactive peptides makes it valuable in pharmaceutical research, particularly in developing new therapeutics targeting various diseases.
  • Bioconjugation: The compound can be used to create bioconjugates, which are essential in developing targeted drug delivery systems, enhancing the efficacy of treatments.
  • Protein Engineering: Researchers utilize it to modify proteins, improving their stability and functionality, which is crucial in biotechnology applications.
  • Analytical Chemistry: Fmoc-O-trityl-L-serine is used in various analytical techniques, including mass spectrometry, to study peptide structures and interactions.

Citations