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Catalog Number:
03502
CAS Number:
133174-15-9
Fmoc-L-citrulline
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Cit-OH, (S)-2-Fmoc-amino-5-ureidopentanoic acid
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Product Information

Fmoc-L-citrulline is a versatile amino acid derivative widely utilized in peptide synthesis and bioconjugation applications. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which allows for selective deprotection during the synthesis of peptides, making it an essential building block for researchers in the fields of medicinal chemistry and biochemistry. Its unique structure not only enhances stability but also improves solubility in organic solvents, facilitating smoother reactions and higher yields.

In addition to its role in peptide synthesis, Fmoc-L-citrulline has shown potential in the development of novel therapeutics and drug delivery systems. Its incorporation into peptides can enhance bioactivity and improve pharmacokinetic properties, making it a valuable asset in pharmaceutical research. Researchers can leverage Fmoc-L-citrulline to create peptides with specific functionalities, paving the way for advancements in targeted therapies and biomaterials.

Synonyms
Fmoc-L-Cit-OH, (S)-2-Fmoc-amino-5-ureidopentanoic acid
CAS Number
133174-15-9
Purity
≥ 99% (HPLC)
Molecular Formula
C21H23N3O5
Molecular Weight
397.4
MDL Number
MFCD00151943
PubChem ID
4224076
Melting Point
156 - 164 °C
Appearance
White powder
Optical Rotation
[a]D20 = -9 ± 1.5 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Cit-OH, (S)-2-Fmoc-amino-5-ureidopentanoic acid
CAS Number
133174-15-9
Purity
≥ 99% (HPLC)
Molecular Formula
C21H23N3O5
Molecular Weight
397.4
MDL Number
MFCD00151943
PubChem ID
4224076
Melting Point
156 - 164 °C
Appearance
White powder
Optical Rotation
[a]D20 = -9 ± 1.5 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-citrulline is widely utilized in research focused on:

  • Peptide Synthesis: This compound is a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the efficient assembly of complex peptide chains.
  • Drug Development: Its unique properties make it valuable in the development of pharmaceuticals, especially in creating peptide-based drugs that can target specific biological pathways.
  • Bioconjugation: Fmoc-L-citrulline can be used to modify biomolecules, enhancing their stability and functionality in various applications, including targeted drug delivery systems.
  • Research in Cardiovascular Health: Studies have shown that citrulline plays a role in nitric oxide production, making it relevant in research aimed at improving cardiovascular function and addressing conditions like hypertension.
  • Cosmetic Formulations: Its potential benefits in skin health have led to its inclusion in cosmetic products, where it may promote hydration and improve skin elasticity.

Citations