Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
02880
CAS Number:
177966-58-4
Fmoc-3,4-dichloro-D-phenylalanine
Purity:
≥ 97% (HPLC)
Synonym(s):
Fmoc-D-Phe(3,4-DiCl)-OH, Fmoc-D-Phe(3,4-Cl2)-OH, (R-Fmoc-2-Amino-3-(3,4-dichlorophenyl)propionic acid
Documents
$86.23 /1G
Pack Size Availability Price
Request Bulk Quote
Product Information

Fmoc-3,4-dichloro-D-phenylalanine is a highly valuable amino acid derivative widely utilized in peptide synthesis and medicinal chemistry. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. The presence of the 3,4-dichlorophenyl moiety enhances its reactivity and allows for the introduction of chlorinated phenyl groups into peptide chains, making it an excellent choice for researchers aiming to develop novel therapeutic peptides with enhanced biological activity.

In addition to its role in peptide synthesis, Fmoc-3,4-dichloro-D-phenylalanine is also significant in the study of structure-activity relationships (SAR) in drug development. Its unique structural features enable researchers to explore various modifications and their effects on biological activity, thus facilitating the design of more effective pharmaceutical agents. This compound is particularly beneficial for those in the fields of medicinal chemistry and biochemistry, as it provides a versatile building block for the development of complex peptide-based drugs.

Synonyms
Fmoc-D-Phe(3,4-DiCl)-OH, Fmoc-D-Phe(3,4-Cl2)-OH, (R-Fmoc-2-Amino-3-(3,4-dichlorophenyl)propionic acid
CAS Number
177966-58-4
Purity
≥ 97% (HPLC)
Molecular Formula
C24H19Cl2NO4
Molecular Weight
456.4
MDL Number
MFCD00273472
PubChem ID
3365122
Appearance
White to off-white solid
Optical Rotation
[a]20D = +30 ± 3º (C= in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-D-Phe(3,4-DiCl)-OH, Fmoc-D-Phe(3,4-Cl2)-OH, (R-Fmoc-2-Amino-3-(3,4-dichlorophenyl)propionic acid
CAS Number
177966-58-4
Purity
≥ 97% (HPLC)
Molecular Formula
C24H19Cl2NO4
Molecular Weight
456.4
MDL Number
MFCD00273472
PubChem ID
3365122
Appearance
White to off-white solid
Optical Rotation
[a]20D = +30 ± 3º (C= in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-3,4-dichloro-D-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences with high purity.
  • Drug Development: It is used in the development of pharmaceutical compounds, especially in designing peptide-based drugs that target specific biological pathways, enhancing therapeutic efficacy.
  • Bioconjugation: The compound facilitates bioconjugation processes, enabling the attachment of peptides to various biomolecules, which is crucial in creating targeted drug delivery systems.
  • Research in Neuroscience: It plays a significant role in studying neuropeptides, contributing to the understanding of neurological functions and potential treatments for neurodegenerative diseases.
  • Protein Engineering: This chemical is employed in protein engineering applications, allowing researchers to modify proteins for improved stability and functionality in various biotechnological applications.

Citations