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Catalog Number:
02670
CAS Number:
77128-73-5
Nα-Fmoc-Nα-Methyl-L-phenylalanine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-N-Me-L-Phe-OH
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Product Information

Na-Fmoc-Na-methyl-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis of peptides, making it an essential building block for researchers in the fields of biochemistry and medicinal chemistry. Its unique structure not only enhances the stability of peptides but also facilitates the introduction of phenylalanine into peptide chains, which can significantly influence the biological activity and pharmacokinetics of the resulting compounds.

In practical applications, Na-Fmoc-Na-methyl-L-phenylalanine is particularly valuable in the synthesis of therapeutic peptides and proteins, where precision and efficiency are paramount. Its ability to improve solubility and stability makes it a preferred choice for researchers aiming to develop novel pharmaceuticals. Additionally, this compound can be employed in the study of protein interactions and enzyme activity, providing insights that are crucial for drug discovery and development.

Synonyms
Fmoc-N-Me-L-Phe-OH
CAS Number
77128-73-5
Purity
≥ 98% (HPLC)
Molecular Formula
C25H23NO4
Molecular Weight
401.5
MDL Number
MFCD00151938
PubChem ID
4083292
Melting Point
128 - 135 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -55 ± 3 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-N-Me-L-Phe-OH
CAS Number
77128-73-5
Purity
≥ 98% (HPLC)
Molecular Formula
C25H23NO4
Molecular Weight
401.5
MDL Number
MFCD00151938
PubChem ID
4083292
Melting Point
128 - 135 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -55 ± 3 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Na-methyl-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in solid-phase peptide synthesis, allowing researchers to create complex peptides efficiently.
  • Drug Development: It is used in the pharmaceutical industry to design and optimize peptide-based drugs, enhancing their efficacy and stability.
  • Bioconjugation: The chemical is valuable in bioconjugation techniques, enabling the attachment of peptides to various biomolecules for targeted drug delivery systems.
  • Protein Engineering: It aids in the modification of proteins, improving their properties for research and therapeutic applications, particularly in the field of biotechnology.
  • Research in Neuroscience: This compound is explored in studies related to neurotransmitter function, contributing to a better understanding of neurological disorders.

Citations