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Catalog Number:
02659
CAS Number:
53363-89-6
Boc-N-methyl-L-leucine
Purity:
≥ 98% (HPLC)
Synonym(s):
Boc-N-Me-L-Leu-OH, Boc-(Neopentyl)gly-OH, Ná-Boc-â-tert-butyl-L-alanine
Documents
$18.53 /1G
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Product Information

Boc-N-methyl-L-leucine is a valuable amino acid derivative widely utilized in peptide synthesis and pharmaceutical research. This compound, known for its protective Boc (tert-butyloxycarbonyl) group, enhances the stability and solubility of peptides during synthesis, making it an essential building block in the development of biologically active compounds. Its unique structure allows for selective reactions, facilitating the creation of complex peptides with improved efficacy and specificity. Researchers in medicinal chemistry and drug development frequently employ Boc-N-methyl-L-leucine to create novel therapeutics, particularly in the fields of oncology and neurology, where precise molecular interactions are crucial.

This compound stands out due to its ability to provide steric hindrance, which can influence the conformation of peptides and enhance their biological activity. Its application in solid-phase peptide synthesis (SPPS) allows for streamlined processes, reducing the time and resources needed for peptide production. With its favorable properties, Boc-N-methyl-L-leucine is an indispensable tool for researchers aiming to innovate in peptide-based drug design and development.

Synonyms
Boc-N-Me-L-Leu-OH, Boc-(Neopentyl)gly-OH, Ná-Boc-â-tert-butyl-L-alanine
CAS Number
53363-89-6
Purity
≥ 98% (HPLC)
Molecular Formula
C12H23NO4
Molecular Weight
245.3
MDL Number
MFCD00038522
PubChem ID
333436
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -35 ± 2 ° (C=1 in DCM)D20 = -30 ± 1 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Boc-N-Me-L-Leu-OH, Boc-(Neopentyl)gly-OH, Ná-Boc-â-tert-butyl-L-alanine
CAS Number
53363-89-6
Purity
≥ 98% (HPLC)
Molecular Formula
C12H23NO4
Molecular Weight
245.3
MDL Number
MFCD00038522
PubChem ID
333436
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -35 ± 2 ° (C=1 in DCM)D20 = -30 ± 1 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Boc-N-methyl-L-leucine is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex and biologically active peptides.
  • Drug Development: It plays a significant role in the pharmaceutical industry for developing new drugs, especially those targeting specific receptors due to its ability to modify peptide structures for enhanced efficacy.
  • Biotechnology: In biotechnology, Boc-N-methyl-L-leucine is used in the production of therapeutic proteins, contributing to advancements in treatments for various diseases.
  • Research Applications: Researchers utilize this compound in studies related to protein folding and stability, helping to understand the mechanisms of protein interactions and functions.
  • Custom Synthesis: It is often employed in custom synthesis projects, providing flexibility for chemists to design specific compounds tailored to their research needs.

Citations