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Catalog Number:
02657
CAS Number:
138775-22-1
Fmoc-N-methyl-L-isoleucine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-N-Me-L-Ile-OH
Documents
$28.04 /1G
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Product Information

Fmoc-N-methyl-L-isoleucine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block for researchers in the field of medicinal chemistry. Its unique structure, characterized by the N-methyl substitution, enhances its stability and solubility, facilitating smoother reactions and higher yields in peptide coupling processes.

Researchers and industry professionals appreciate Fmoc-N-methyl-L-isoleucine for its application in the synthesis of bioactive peptides, particularly those that require specific stereochemistry or enhanced pharmacological properties. Its ability to improve the pharmacokinetic profiles of peptides makes it a valuable asset in drug formulation and development. Additionally, its compatibility with various coupling reagents and methodologies further underscores its importance in peptide chemistry, allowing for the efficient assembly of complex peptide sequences.

Synonyms
Fmoc-N-Me-L-Ile-OH
CAS Number
138775-22-1
Purity
≥ 99% (HPLC)
Molecular Formula
C22H25NO4
Molecular Weight
367.4
MDL Number
MFCD00153389
PubChem ID
3473752
Melting Point
168 - 176 ?C
Appearance
White powder
Optical Rotation
[a]D20 = -59 ± 2 º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-N-Me-L-Ile-OH
CAS Number
138775-22-1
Purity
≥ 99% (HPLC)
Molecular Formula
C22H25NO4
Molecular Weight
367.4
MDL Number
MFCD00153389
PubChem ID
3473752
Melting Point
168 - 176 ?C
Appearance
White powder
Optical Rotation
[a]D20 = -59 ± 2 º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-N-methyl-L-isoleucine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis. Its Fmoc protecting group allows for easy removal during the synthesis process, making it a preferred choice for researchers.
  • Drug Development: In pharmaceutical research, it is used to create peptide-based drugs. Its unique structure can enhance the bioactivity of peptides, leading to more effective therapeutic agents.
  • Bioconjugation: The compound is employed in bioconjugation techniques, where it helps link peptides to other biomolecules, such as antibodies or enzymes, facilitating targeted drug delivery systems.
  • Protein Engineering: Researchers utilize this compound to modify proteins, improving their stability and functionality. This is particularly beneficial in developing enzymes with enhanced catalytic properties.
  • Analytical Chemistry: It is also used in analytical methods to study protein interactions and conformational changes, providing insights into protein behavior in various environments.

Citations