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Catalog Number:
02588
CAS Number:
112883-43-9
Fmoc-3-(2-naphthyl)-L-alanine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Ala(2-naphthyl)-OH, Fmoc-(S)-2-amino-3-(naphthalen-2-yl)propanoic acid, Fmoc-Ala(2-naphthyl)-OH
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Product Information

Fmoc-3-(2-naphthyl)-L-alanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique structure, characterized by the presence of a naphthyl group, enhances the stability and solubility of peptides, making it an ideal choice for researchers focusing on complex peptide sequences.

In practical applications, Fmoc-3-(2-naphthyl)-L-alanine is particularly valuable in the pharmaceutical industry for the development of novel therapeutics, including those targeting cancer and neurological disorders. Its ability to facilitate the formation of stable peptide bonds allows for the efficient assembly of bioactive peptides, which can lead to the discovery of new drug candidates. Additionally, this compound's compatibility with various coupling reagents and its ease of deprotection make it a preferred choice among chemists and researchers in the field of medicinal chemistry.

Synonyms
Fmoc-L-Ala(2-naphthyl)-OH, Fmoc-(S)-2-amino-3-(naphthalen-2-yl)propanoic acid, Fmoc-Ala(2-naphthyl)-OH
CAS Number
112883-43-9
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C28H23NO4
Molecular Weight
437.5
MDL Number
MFCD00144886
PubChem ID
7130588
Melting Point
157 - 168 ?C
Appearance
White powder
Optical Rotation
[a]D25 = -15 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Ala(2-naphthyl)-OH, Fmoc-(S)-2-amino-3-(naphthalen-2-yl)propanoic acid, Fmoc-Ala(2-naphthyl)-OH
CAS Number
112883-43-9
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C28H23NO4
Molecular Weight
437.5
MDL Number
MFCD00144886
PubChem ID
7130588
Melting Point
157 - 168 ?C
Appearance
White powder
Optical Rotation
[a]D25 = -15 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-3-(2-naphthyl)-L-alanine is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex peptide sequences with high purity.
  • Drug Development: Its unique structure makes it valuable in the pharmaceutical industry for developing novel drug candidates that target specific biological pathways, enhancing therapeutic efficacy.
  • Bioconjugation: The chemical is used in bioconjugation techniques, facilitating the attachment of biomolecules to surfaces or other molecules, which is crucial in creating targeted drug delivery systems.
  • Research in Cancer Therapeutics: Researchers leverage its properties in studies aimed at developing cancer treatments, particularly those that involve targeting specific cancer cell receptors.
  • Fluorescent Probes: The naphthyl group in this compound can be utilized to create fluorescent probes for imaging applications, aiding in the visualization of cellular processes in biological research.

Citations