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Catalog Number:
02584
CAS Number:
96402-49-2
Fmoc-3-(1-naphthyl)-L-alanine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Ala(1-naphthyl)-OH, Fmoc-(S)-2-amino-3-(naphthalen-1-yl)propanoic acid, Fmoc-Ala(1-naphthyl)-OH
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Product Information

Fmoc-3-(1-naphthyl)-L-alanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique structure, characterized by the naphthyl side chain, enhances the stability and solubility of peptides, making it an ideal choice for researchers focused on developing complex peptide-based therapeutics.

In addition to its role in peptide synthesis, Fmoc-3-(1-naphthyl)-L-alanine is also valuable in the study of protein interactions and conformational studies due to its ability to mimic natural amino acids while providing distinct spectroscopic properties. This compound is particularly beneficial in the pharmaceutical industry, where it aids in the design of novel drugs with improved efficacy and reduced side effects. Its application in combinatorial chemistry and high-throughput screening further underscores its importance in modern medicinal chemistry.

Synonyms
Fmoc-L-Ala(1-naphthyl)-OH, Fmoc-(S)-2-amino-3-(naphthalen-1-yl)propanoic acid, Fmoc-Ala(1-naphthyl)-OH
CAS Number
96402-49-2
Purity
≥ 99% (HPLC)
Molecular Formula
C28H23NO4
Molecular Weight
437.5
MDL Number
MFCD00151914
PubChem ID
3462522
Melting Point
180 - 190 °C (Lit.)
Appearance
White powder
Optical Rotation
[a]D20 = -21 ± 2 º (C=1 in Dioxane)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Ala(1-naphthyl)-OH, Fmoc-(S)-2-amino-3-(naphthalen-1-yl)propanoic acid, Fmoc-Ala(1-naphthyl)-OH
CAS Number
96402-49-2
Purity
≥ 99% (HPLC)
Molecular Formula
C28H23NO4
Molecular Weight
437.5
MDL Number
MFCD00151914
PubChem ID
3462522
Melting Point
180 - 190 °C (Lit.)
Appearance
White powder
Optical Rotation
[a]D20 = -21 ± 2 º (C=1 in Dioxane)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-3-(1-naphthyl)-L-alanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in solid-phase peptide synthesis, allowing for the selective modification of amino acids without interfering with other functional groups.
  • Drug Development: Its unique structure aids in the design of peptide-based therapeutics, particularly in targeting specific biological pathways, enhancing drug efficacy.
  • Bioconjugation: The compound is used in bioconjugation processes, facilitating the attachment of peptides to various biomolecules, which is crucial for developing targeted drug delivery systems.
  • Fluorescent Probes: It can be incorporated into fluorescent probes for imaging applications in biological research, providing insights into cellular processes.
  • Research in Neuroscience: The compound is explored in studies related to neuropeptides, contributing to the understanding of neurological functions and potential treatments for neurodegenerative diseases.

Citations